Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.

Studies in populations of European descent show longer plasma clot lysis times (CLT) in patients with cardiovascular disease (CVD) than in controls. No data are available on the association between CVD risk factors and fibrinolytic potential in black Africans, a group undergoing rapid urbanisation w...

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Autores principales:	Zelda de Lange, Marlien Pieters, Johann C Jerling, Annamarie Kruger, Dingeman C Rijken
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9486cb8daae548ebba81fef8410a11f7
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spelling	oai:doaj.org-article:9486cb8daae548ebba81fef8410a11f72021-11-18T08:09:24ZPlasma clot lysis time and its association with cardiovascular risk factors in black Africans.1932-620310.1371/journal.pone.0048881https://doaj.org/article/9486cb8daae548ebba81fef8410a11f72012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23145007/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Studies in populations of European descent show longer plasma clot lysis times (CLT) in patients with cardiovascular disease (CVD) than in controls. No data are available on the association between CVD risk factors and fibrinolytic potential in black Africans, a group undergoing rapid urbanisation with increased CVD prevalence. We investigated associations between known CVD risk factors and CLT in black Africans and whether CLTs differ between rural and urban participants in light of differences in CVD risk.Data from 1000 rural and 1000 urban apparently healthy black South Africans (35-60 years) were cross-sectionally analysed.Increased PAI-1(act), BMI, HbA1c, triglycerides, the metabolic syndrome, fibrinogen concentration, CRP, female sex and positive HIV status were associated with increased CLTs, while habitual alcohol consumption associated with decreased CLT. No differences in CLT were found between age and smoking categories, contraceptive use or hyper- and normotensive participants. Urban women had longer CLT than rural women while no differences were observed for men.CLT was associated with many known CVD risk factors in black Africans. Differences were however observed, compared to data from populations of European descent available in the literature, suggesting possible ethnic differences. The effect of urbanisation on CLT is influenced by traditional CVD risk factors and their prevalence in urban and rural communities.Zelda de LangeMarlien PietersJohann C JerlingAnnamarie KrugerDingeman C RijkenPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e48881 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zelda de Lange Marlien Pieters Johann C Jerling Annamarie Kruger Dingeman C Rijken Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.
description	Studies in populations of European descent show longer plasma clot lysis times (CLT) in patients with cardiovascular disease (CVD) than in controls. No data are available on the association between CVD risk factors and fibrinolytic potential in black Africans, a group undergoing rapid urbanisation with increased CVD prevalence. We investigated associations between known CVD risk factors and CLT in black Africans and whether CLTs differ between rural and urban participants in light of differences in CVD risk.Data from 1000 rural and 1000 urban apparently healthy black South Africans (35-60 years) were cross-sectionally analysed.Increased PAI-1(act), BMI, HbA1c, triglycerides, the metabolic syndrome, fibrinogen concentration, CRP, female sex and positive HIV status were associated with increased CLTs, while habitual alcohol consumption associated with decreased CLT. No differences in CLT were found between age and smoking categories, contraceptive use or hyper- and normotensive participants. Urban women had longer CLT than rural women while no differences were observed for men.CLT was associated with many known CVD risk factors in black Africans. Differences were however observed, compared to data from populations of European descent available in the literature, suggesting possible ethnic differences. The effect of urbanisation on CLT is influenced by traditional CVD risk factors and their prevalence in urban and rural communities.
format	article
author	Zelda de Lange Marlien Pieters Johann C Jerling Annamarie Kruger Dingeman C Rijken
author_facet	Zelda de Lange Marlien Pieters Johann C Jerling Annamarie Kruger Dingeman C Rijken
author_sort	Zelda de Lange
title	Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.
title_short	Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.
title_full	Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.
title_fullStr	Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.
title_full_unstemmed	Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.
title_sort	plasma clot lysis time and its association with cardiovascular risk factors in black africans.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/9486cb8daae548ebba81fef8410a11f7
work_keys_str_mv	AT zeldadelange plasmaclotlysistimeanditsassociationwithcardiovascularriskfactorsinblackafricans AT marlienpieters plasmaclotlysistimeanditsassociationwithcardiovascularriskfactorsinblackafricans AT johanncjerling plasmaclotlysistimeanditsassociationwithcardiovascularriskfactorsinblackafricans AT annamariekruger plasmaclotlysistimeanditsassociationwithcardiovascularriskfactorsinblackafricans AT dingemancrijken plasmaclotlysistimeanditsassociationwithcardiovascularriskfactorsinblackafricans
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Plasma clot lysis time and its association with cardiovascular risk factors in black Africans.

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