Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities

Abstract Previous research has indicated that temporal changes of centrality of specific nodes in human evolving large-scale epileptic brain networks carry information predictive of impending seizures. Centrality is a fundamental network-theoretical concept that allows one to assess the role a node...

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Autores principales:	Rieke Fruengel, Timo Bröhl, Thorsten Rings, Klaus Lehnertz
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/9486e3cd1642416b91ccc51ca4de26e2
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spelling	oai:doaj.org-article:9486e3cd1642416b91ccc51ca4de26e22021-12-02T11:57:57ZReconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities10.1038/s41598-020-78899-72045-2322https://doaj.org/article/9486e3cd1642416b91ccc51ca4de26e22020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78899-7https://doaj.org/toc/2045-2322Abstract Previous research has indicated that temporal changes of centrality of specific nodes in human evolving large-scale epileptic brain networks carry information predictive of impending seizures. Centrality is a fundamental network-theoretical concept that allows one to assess the role a node plays in a network. This concept allows for various interpretations, which is reflected in a number of centrality indices. Here we aim to achieve a more general understanding of local and global network reconfigurations during the pre-seizure period as indicated by changes of different node centrality indices. To this end, we investigate—in a time-resolved manner—evolving large-scale epileptic brain networks that we derived from multi-day, multi-electrode intracranial electroencephalograpic recordings from a large but inhomogeneous group of subjects with pharmacoresistant epilepsies with different anatomical origins. We estimate multiple centrality indices to assess the various roles the nodes play while the networks transit from the seizure-free to the pre-seizure period. Our findings allow us to formulate several major scenarios for the reconfiguration of an evolving epileptic brain network prior to seizures, which indicate that there is likely not a single network mechanism underlying seizure generation. Rather, local and global aspects of the pre-seizure network reconfiguration affect virtually all network constituents, from the various brain regions to the functional connections between them.Rieke FruengelTimo BröhlThorsten RingsKlaus LehnertzNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rieke Fruengel Timo Bröhl Thorsten Rings Klaus Lehnertz Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
description	Abstract Previous research has indicated that temporal changes of centrality of specific nodes in human evolving large-scale epileptic brain networks carry information predictive of impending seizures. Centrality is a fundamental network-theoretical concept that allows one to assess the role a node plays in a network. This concept allows for various interpretations, which is reflected in a number of centrality indices. Here we aim to achieve a more general understanding of local and global network reconfigurations during the pre-seizure period as indicated by changes of different node centrality indices. To this end, we investigate—in a time-resolved manner—evolving large-scale epileptic brain networks that we derived from multi-day, multi-electrode intracranial electroencephalograpic recordings from a large but inhomogeneous group of subjects with pharmacoresistant epilepsies with different anatomical origins. We estimate multiple centrality indices to assess the various roles the nodes play while the networks transit from the seizure-free to the pre-seizure period. Our findings allow us to formulate several major scenarios for the reconfiguration of an evolving epileptic brain network prior to seizures, which indicate that there is likely not a single network mechanism underlying seizure generation. Rather, local and global aspects of the pre-seizure network reconfiguration affect virtually all network constituents, from the various brain regions to the functional connections between them.
format	article
author	Rieke Fruengel Timo Bröhl Thorsten Rings Klaus Lehnertz
author_facet	Rieke Fruengel Timo Bröhl Thorsten Rings Klaus Lehnertz
author_sort	Rieke Fruengel
title	Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
title_short	Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
title_full	Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
title_fullStr	Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
title_full_unstemmed	Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
title_sort	reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/9486e3cd1642416b91ccc51ca4de26e2
work_keys_str_mv	AT riekefruengel reconfigurationofhumanevolvinglargescaleepilepticbrainnetworkspriortoseizuresanevaluationwithnodecentralities AT timobrohl reconfigurationofhumanevolvinglargescaleepilepticbrainnetworkspriortoseizuresanevaluationwithnodecentralities AT thorstenrings reconfigurationofhumanevolvinglargescaleepilepticbrainnetworkspriortoseizuresanevaluationwithnodecentralities AT klauslehnertz reconfigurationofhumanevolvinglargescaleepilepticbrainnetworkspriortoseizuresanevaluationwithnodecentralities
_version_	1718394763266228224

Reconfiguration of human evolving large-scale epileptic brain networks prior to seizures: an evaluation with node centralities

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