From micro- to nanostructured implantable device for local anesthetic delivery

Laura Zorzetto,1 Paola Brambilla,1 Elena Marcello,1 Nora Bloise,2 Manuela De Gregori,3 Lorenzo Cobianchi,4,5 Andrea Peloso,4,5 Massimo Allegri,6 Livia Visai,2,7 Paola Petrini1 1Department of Chemistry, Materials and Chemical Engineering ‘G. Natta’, Politecnico di Milano, Milan,...

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Autores principales:	Zorzetto L, Brambilla P, Marcello E, Bloise N, De Gregori M, Cobianchi L, Peloso A, Allegri M, Visai L, Petrini P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Local anesthetics drug delivery systems micro-structured materials nano-structured materials nano-structured implantable devices Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/948938838c0c41759199ae075797d1c1
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spelling	oai:doaj.org-article:948938838c0c41759199ae075797d1c12021-12-02T07:28:04ZFrom micro- to nanostructured implantable device for local anesthetic delivery1178-2013https://doaj.org/article/948938838c0c41759199ae075797d1c12016-06-01T00:00:00Zhttps://www.dovepress.com/from-micro--to-nanostructured-implantable-device-for-local-anesthetic--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Laura Zorzetto,1 Paola Brambilla,1 Elena Marcello,1 Nora Bloise,2 Manuela De Gregori,3 Lorenzo Cobianchi,4,5 Andrea Peloso,4,5 Massimo Allegri,6 Livia Visai,2,7 Paola Petrini1 1Department of Chemistry, Materials and Chemical Engineering ‘G. Natta’, Politecnico di Milano, Milan, 2Department of Molecular Medicine, Centre for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, 3Pain Therapy Service, IRCCS Foundation Policlinico San Matteo Pavia, Pavia, 4General Surgery Department, IRCCS Foundation Policlinico San Matteo, Pavia, 5Departments of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, 6Department of Surgical Sciences, University of Parma, Parma, 7Department of Occupational Medicine, Toxicology and Environmental Risks, S. Maugeri Foundation, IRCCS, Lab of Nanotechnology, Pavia, Italy Abstract: Local anesthetics block the transmission of painful stimuli to the brain by acting on ion channels of nociceptor fibers, and find application in the management of acute and chronic pain. Despite the key role they play in modern medicine, their cardio and neurotoxicity (together with their short half-life) stress the need for developing implantable devices for tailored local drug release, with the aim of counterbalancing their side effects and prolonging their pharmacological activity. This review discusses the evolution of the physical forms of local anesthetic delivery systems during the past decades. Depending on the use of different biocompatible materials (degradable polyesters, thermosensitive hydrogels, and liposomes and hydrogels from natural polymers) and manufacturing processes, these systems can be classified as films or micro- or nanostructured devices. We analyze and summarize the production techniques according to this classification, focusing on their relative advantages and disadvantages. The most relevant trend reported in this work highlights the effort of moving from microstructured to nanostructured systems, with the aim of reaching a scale comparable to the biological environment. Improved intracellular penetration compared to microstructured systems, indeed, provides specific drug absorption into the targeted tissue and can lead to an enhancement of its bioavailability and retention time. Nanostructured systems are realized by the modification of existing manufacturing processes (interfacial deposition and nanoprecipitation for degradable polyester particles and high- or low-temperature homogenization for liposomes) or development of novel strategies (electrospun matrices and nanogels). The high surface-to-volume ratio that characterizes nanostructured devices often leads to a burst drug release. This drawback needs to be addressed to fully exploit the advantage of the interaction between the target tissues and the drug: possible strategies could involve specific binding between the drug and the material chosen for the device, and a multiscale approach to reach a tailored, prolonged drug release. Keywords: pain management, microparticle, microencapsulation, nanoparticle production, nanogels, liposomesZorzetto LBrambilla PMarcello EBloise NDe Gregori MCobianchi LPeloso AAllegri MVisai LPetrini PDove Medical PressarticleLocal anestheticsdrug delivery systemsmicro-structured materialsnano-structured materialsnano-structured implantable devicesMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 2695-2709 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Local anesthetics drug delivery systems micro-structured materials nano-structured materials nano-structured implantable devices Medicine (General) R5-920
spellingShingle	Local anesthetics drug delivery systems micro-structured materials nano-structured materials nano-structured implantable devices Medicine (General) R5-920 Zorzetto L Brambilla P Marcello E Bloise N De Gregori M Cobianchi L Peloso A Allegri M Visai L Petrini P From micro- to nanostructured implantable device for local anesthetic delivery
description	Laura Zorzetto,1 Paola Brambilla,1 Elena Marcello,1 Nora Bloise,2 Manuela De Gregori,3 Lorenzo Cobianchi,4,5 Andrea Peloso,4,5 Massimo Allegri,6 Livia Visai,2,7 Paola Petrini1 1Department of Chemistry, Materials and Chemical Engineering ‘G. Natta’, Politecnico di Milano, Milan, 2Department of Molecular Medicine, Centre for Health Technologies (CHT), INSTM UdR of Pavia, University of Pavia, 3Pain Therapy Service, IRCCS Foundation Policlinico San Matteo Pavia, Pavia, 4General Surgery Department, IRCCS Foundation Policlinico San Matteo, Pavia, 5Departments of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, Pavia, 6Department of Surgical Sciences, University of Parma, Parma, 7Department of Occupational Medicine, Toxicology and Environmental Risks, S. Maugeri Foundation, IRCCS, Lab of Nanotechnology, Pavia, Italy Abstract: Local anesthetics block the transmission of painful stimuli to the brain by acting on ion channels of nociceptor fibers, and find application in the management of acute and chronic pain. Despite the key role they play in modern medicine, their cardio and neurotoxicity (together with their short half-life) stress the need for developing implantable devices for tailored local drug release, with the aim of counterbalancing their side effects and prolonging their pharmacological activity. This review discusses the evolution of the physical forms of local anesthetic delivery systems during the past decades. Depending on the use of different biocompatible materials (degradable polyesters, thermosensitive hydrogels, and liposomes and hydrogels from natural polymers) and manufacturing processes, these systems can be classified as films or micro- or nanostructured devices. We analyze and summarize the production techniques according to this classification, focusing on their relative advantages and disadvantages. The most relevant trend reported in this work highlights the effort of moving from microstructured to nanostructured systems, with the aim of reaching a scale comparable to the biological environment. Improved intracellular penetration compared to microstructured systems, indeed, provides specific drug absorption into the targeted tissue and can lead to an enhancement of its bioavailability and retention time. Nanostructured systems are realized by the modification of existing manufacturing processes (interfacial deposition and nanoprecipitation for degradable polyester particles and high- or low-temperature homogenization for liposomes) or development of novel strategies (electrospun matrices and nanogels). The high surface-to-volume ratio that characterizes nanostructured devices often leads to a burst drug release. This drawback needs to be addressed to fully exploit the advantage of the interaction between the target tissues and the drug: possible strategies could involve specific binding between the drug and the material chosen for the device, and a multiscale approach to reach a tailored, prolonged drug release. Keywords: pain management, microparticle, microencapsulation, nanoparticle production, nanogels, liposomes
format	article
author	Zorzetto L Brambilla P Marcello E Bloise N De Gregori M Cobianchi L Peloso A Allegri M Visai L Petrini P
author_facet	Zorzetto L Brambilla P Marcello E Bloise N De Gregori M Cobianchi L Peloso A Allegri M Visai L Petrini P
author_sort	Zorzetto L
title	From micro- to nanostructured implantable device for local anesthetic delivery
title_short	From micro- to nanostructured implantable device for local anesthetic delivery
title_full	From micro- to nanostructured implantable device for local anesthetic delivery
title_fullStr	From micro- to nanostructured implantable device for local anesthetic delivery
title_full_unstemmed	From micro- to nanostructured implantable device for local anesthetic delivery
title_sort	from micro- to nanostructured implantable device for local anesthetic delivery
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/948938838c0c41759199ae075797d1c1
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From micro- to nanostructured implantable device for local anesthetic delivery

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