Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.

To determine whether preoperative white blood cell (WBC) counts reflect risk of anastomotic leak (AL) for patients with colorectal cancer (CRC), we retrospectively examined data from records of 208 consecutive patients who had undergone resections for left-sided CRC, including their clinicopathologi...

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Autores principales:	Masaki Morimoto, Kenjiro Taniguchi, Osamu Yamamoto, Takuji Naka, Atsushi Sugitani, Yoshiyuki Fujiwara
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/948a53b088054b2cbcd8c636adc7612a
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spelling	oai:doaj.org-article:948a53b088054b2cbcd8c636adc7612a2021-12-02T20:16:44ZPreoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.1932-620310.1371/journal.pone.0258713https://doaj.org/article/948a53b088054b2cbcd8c636adc7612a2021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258713https://doaj.org/toc/1932-6203To determine whether preoperative white blood cell (WBC) counts reflect risk of anastomotic leak (AL) for patients with colorectal cancer (CRC), we retrospectively examined data from records of 208 consecutive patients who had undergone resections for left-sided CRC, including their clinicopathological parameters and preoperative laboratory data. The diagnostic value of WBC count for AL was evaluated and compared with those of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio and platelet count × C-reactive protein level multiplier (P-CRP) value; optimal cut-off values were derived from receiver operating characteristic curves. AL was observed in 11 of the 208 patients (5.3%). Compared with the no-AL group, the AL group had a significantly higher mean WBC count and smoking rate. In multivariate analysis, WBC count and smoking were independent risk factors for AL. Compared with the other tested inflammatory indicators, the cut-off value for WBC (6,200/μL) had the highest sensitivity (81.8%) and negative predictive value (98.4%), as well as the lowest likelihood ratio (0.289). Preoperative WBC count could therefore be a convenient predictor of AL in patients with left-sided CRC.Masaki MorimotoKenjiro TaniguchiOsamu YamamotoTakuji NakaAtsushi SugitaniYoshiyuki FujiwaraPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258713 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Masaki Morimoto Kenjiro Taniguchi Osamu Yamamoto Takuji Naka Atsushi Sugitani Yoshiyuki Fujiwara Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
description	To determine whether preoperative white blood cell (WBC) counts reflect risk of anastomotic leak (AL) for patients with colorectal cancer (CRC), we retrospectively examined data from records of 208 consecutive patients who had undergone resections for left-sided CRC, including their clinicopathological parameters and preoperative laboratory data. The diagnostic value of WBC count for AL was evaluated and compared with those of neutrophil-lymphocyte ratio, platelet-lymphocyte ratio, lymphocyte-monocyte ratio and platelet count × C-reactive protein level multiplier (P-CRP) value; optimal cut-off values were derived from receiver operating characteristic curves. AL was observed in 11 of the 208 patients (5.3%). Compared with the no-AL group, the AL group had a significantly higher mean WBC count and smoking rate. In multivariate analysis, WBC count and smoking were independent risk factors for AL. Compared with the other tested inflammatory indicators, the cut-off value for WBC (6,200/μL) had the highest sensitivity (81.8%) and negative predictive value (98.4%), as well as the lowest likelihood ratio (0.289). Preoperative WBC count could therefore be a convenient predictor of AL in patients with left-sided CRC.
format	article
author	Masaki Morimoto Kenjiro Taniguchi Osamu Yamamoto Takuji Naka Atsushi Sugitani Yoshiyuki Fujiwara
author_facet	Masaki Morimoto Kenjiro Taniguchi Osamu Yamamoto Takuji Naka Atsushi Sugitani Yoshiyuki Fujiwara
author_sort	Masaki Morimoto
title	Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
title_short	Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
title_full	Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
title_fullStr	Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
title_full_unstemmed	Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
title_sort	preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/948a53b088054b2cbcd8c636adc7612a
work_keys_str_mv	AT masakimorimoto preoperativewhitebloodcellcountpredictsanastomoticleakageinpatientswithleftsidedcolorectalcancer AT kenjirotaniguchi preoperativewhitebloodcellcountpredictsanastomoticleakageinpatientswithleftsidedcolorectalcancer AT osamuyamamoto preoperativewhitebloodcellcountpredictsanastomoticleakageinpatientswithleftsidedcolorectalcancer AT takujinaka preoperativewhitebloodcellcountpredictsanastomoticleakageinpatientswithleftsidedcolorectalcancer AT atsushisugitani preoperativewhitebloodcellcountpredictsanastomoticleakageinpatientswithleftsidedcolorectalcancer AT yoshiyukifujiwara preoperativewhitebloodcellcountpredictsanastomoticleakageinpatientswithleftsidedcolorectalcancer
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Preoperative white blood cell count predicts anastomotic leakage in patients with left-sided colorectal cancer.

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