Antitrypanosomal Activity of <i>Anthriscus</i> Nemorosa Essential Oils and Combinations of Their Main Constituents
This study aimed to investigate the susceptibility of <i>Trypanosoma brucei</i> to the <i>Anthriscus nemorosa</i> essential oils (EOs), isolated compounds from these oils, and artificial mixtures of the isolated compounds in their conventional and nanoencapsulated forms. The...
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| Autores principales: | , , , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/948d155ad812401b81bf7e1071b0c755 |
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| Sumario: | This study aimed to investigate the susceptibility of <i>Trypanosoma brucei</i> to the <i>Anthriscus nemorosa</i> essential oils (EOs), isolated compounds from these oils, and artificial mixtures of the isolated compounds in their conventional and nanoencapsulated forms. The chemical composition of the essential oils from the aerial parts and roots of <i>Anthriscus nemorosa</i>, obtained from a wild population growing in central Italy, were analyzed by gas chromatography/mass spectrometry (GC/MS). In both cases, the predominant class of compounds was monoterpene hydrocarbons, which were more abundant in the EOs from the roots (81.5%) than the aerial parts (74.0%). The overall results of this work have shed light on the biological properties of <i>A. nemorosa</i> EO from aerial parts (EC<sub>50</sub> = 1.17 μg/mL), farnesene (EC<sub>50</sub> = 0.84 μg/mL), and artificial mixtures (Mix 3–5, EC<sub>50</sub> in the range of 1.27 to 1.58 μg/mL) as relevant sources of antiprotozoal substances. Furthermore, the pool measurements of ADP (adenosine diphosphate) and NTPs (nucleoside triphosphates) in the cultivated bloodstream form of trypanosomes exposed to different concentrations of EOs showed a disturbed energy metabolism, as indicated by increased pools of ADP in comparison to ATP (adenosine triphosphate) and other NTPs. Ultimately, this study highlights the significant efficacy of <i>A. nemorosa</i> EO to develop long-lasting and effective antiprotozoal formulations, including nanoemulsions. |
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