MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury

Ischemia-reperfusion (I/R) injury is a progressive injury that aggravates the pathological state when the organ tissue restores blood supply after a certain period of ischemia, including the myocardial, brain, liver, kidney, and intestinal. With growing evidence that microRNAs (miRNAs) play an impor...

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Autores principales:	Mingming Cao, Wenjing Song, Runyu Liang, Lili Teng, Mei Zhang, Jiyao Zhang, Luwen Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/948d3ffa908648129144294e4498e78e
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spelling	oai:doaj.org-article:948d3ffa908648129144294e4498e78e2021-11-29T00:56:58ZMicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury2314-437810.1155/2021/9098145https://doaj.org/article/948d3ffa908648129144294e4498e78e2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9098145https://doaj.org/toc/2314-4378Ischemia-reperfusion (I/R) injury is a progressive injury that aggravates the pathological state when the organ tissue restores blood supply after a certain period of ischemia, including the myocardial, brain, liver, kidney, and intestinal. With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. In addition, we discussed the potential role of miRNA as a biomarker and its role as a target in I/R injury treatment. Developing miRNAs are not without its challenges, but prudent design combined with existing clinical treatments will result in more effective therapies for I/R injury. This review is aimed at providing new research results obtained in this research field. It is hoped that new research on this topic will not only generate new insights into the pathophysiology of miRNA in I/R injury but also can provide a basis for the clinical application of miRNA in I/R.Mingming CaoWenjing SongRunyu LiangLili TengMei ZhangJiyao ZhangLuwen ZhuHindawi LimitedarticleGeneticsQH426-470ENInternational Journal of Genomics, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Mingming Cao Wenjing Song Runyu Liang Lili Teng Mei Zhang Jiyao Zhang Luwen Zhu MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury
description	Ischemia-reperfusion (I/R) injury is a progressive injury that aggravates the pathological state when the organ tissue restores blood supply after a certain period of ischemia, including the myocardial, brain, liver, kidney, and intestinal. With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. In addition, we discussed the potential role of miRNA as a biomarker and its role as a target in I/R injury treatment. Developing miRNAs are not without its challenges, but prudent design combined with existing clinical treatments will result in more effective therapies for I/R injury. This review is aimed at providing new research results obtained in this research field. It is hoped that new research on this topic will not only generate new insights into the pathophysiology of miRNA in I/R injury but also can provide a basis for the clinical application of miRNA in I/R.
format	article
author	Mingming Cao Wenjing Song Runyu Liang Lili Teng Mei Zhang Jiyao Zhang Luwen Zhu
author_facet	Mingming Cao Wenjing Song Runyu Liang Lili Teng Mei Zhang Jiyao Zhang Luwen Zhu
author_sort	Mingming Cao
title	MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury
title_short	MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury
title_full	MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury
title_fullStr	MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury
title_full_unstemmed	MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury
title_sort	microrna as a potential biomarker and treatment strategy for ischemia-reperfusion injury
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/948d3ffa908648129144294e4498e78e
work_keys_str_mv	AT mingmingcao micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury AT wenjingsong micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury AT runyuliang micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury AT liliteng micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury AT meizhang micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury AT jiyaozhang micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury AT luwenzhu micrornaasapotentialbiomarkerandtreatmentstrategyforischemiareperfusioninjury
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MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury

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