Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension

Yuling Yu,1,&ast; Yuqing Huang,1,&ast; Lin Liu,2 Xiao-Cong Liu,1 Qiuhong Tan,3 Chaolei Chen,1 Jiayi Huang,3 Yingqing Feng,1 Songtao Tang4 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 5...

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Autores principales:	Yu Y, Huang Y, Liu L, Liu XC, Tan Q, Chen C, Huang J, Feng Y, Tang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	vascular overload index ischemic stroke hypertension elderly population blood vessel Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/948e3f3f5998415d842fb8a197d1245f
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spelling	oai:doaj.org-article:948e3f3f5998415d842fb8a197d1245f2021-12-02T16:24:32ZAssociation Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension1178-1998https://doaj.org/article/948e3f3f5998415d842fb8a197d1245f2021-07-01T00:00:00Zhttps://www.dovepress.com/association-between-vascular-overload-index-and-new-onset-ischemic-str-peer-reviewed-fulltext-article-CIAhttps://doaj.org/toc/1178-1998Yuling Yu,1,&ast; Yuqing Huang,1,&ast; Lin Liu,2 Xiao-Cong Liu,1 Qiuhong Tan,3 Chaolei Chen,1 Jiayi Huang,3 Yingqing Feng,1 Songtao Tang4 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China; 2The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Guangdong Provincial People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, People’s Republic of China; 4Department of Cardiology, Community Health Center of Liaobu Town, Dongguan, 523400, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Songtao TangDepartment of Cardiology, Community Health Center of Liaobu Town, Dongguan, 523400, Guangdong, People’s Republic of ChinaEmail 3038384760@qq.comYingqing FengDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 106 2nd Zhongshan Road, Yuexiu District, Guangzhou, 510080, People’s Republic of ChinaEmail fengyingqing@gdph.org.cnBackground: Vascular overload index (VOI) is a marker of arterial stiffness and arteriolar resistance, which predicts the increasing risks of cardiovascular and cerebrovascular disease. This study aimed to evaluate the association between VOI and new-onset ischemic stroke in an elderly population with hypertension.Methods: This retrospective cohort study included 3315 hypertensive participants aged 60 years or more. Ischemic stroke was diagnosed according to cranial computed tomography, magnetic resonance imaging of the brain or cerebrovascular angiography. The calculation of VOI was based on systolic and diastolic blood pressure. VOI was divided by quartiles (< 7.88 mmHg, 7.88– 16.10 mmHg, 16.10– 27.14 mmHg, ≥ 27.14 mmHg) and evaluated the association with new-onset ischemic stroke by multivariable Cox regression models.Results: A total of 3315 participants (55.5% female) aged 71.4± 7.20 years were included in the analysis. The median follow-up period was 5.5 years, and 206 participants reached the endpoint, new-onset ischemic stroke. With per standard deviation increment in VOI, the risks of new-onset ischemic stroke increased in non-adjusted model (Hazard ratio [HR], 1.11; 95% confidence interval [CI]: 1.03– 1.22; p = 0.001), adjusted model (HR, 1.11; 95% CI: 1.04– 1.22; p = 0.003) and fully-adjusted model (HR, 1.15; 95% CI: 1.08– 1.26; p< 0.001), respectively. In multivariate fully adjusted model, the risks of ischemic stroke increased in higher quartiles in comparison to the first quartiles (p for trend < 0.001).Conclusion: In an elderly hypertensive population, VOI is significantly associated with the incidence of new-onset ischemic stroke. Elevated VOI is the cardiovascular risk factor and increases the probability of new-onset ischemic stroke.Keywords: vascular overload index, ischemic stroke, hypertension, elderly population, blood vesselYu YHuang YLiu LLiu XCTan QChen CHuang JFeng YTang SDove Medical Pressarticlevascular overload indexischemic strokehypertensionelderly populationblood vesselGeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 16, Pp 1293-1301 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	vascular overload index ischemic stroke hypertension elderly population blood vessel Geriatrics RC952-954.6
spellingShingle	vascular overload index ischemic stroke hypertension elderly population blood vessel Geriatrics RC952-954.6 Yu Y Huang Y Liu L Liu XC Tan Q Chen C Huang J Feng Y Tang S Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension
description	Yuling Yu,1,&ast; Yuqing Huang,1,&ast; Lin Liu,2 Xiao-Cong Liu,1 Qiuhong Tan,3 Chaolei Chen,1 Jiayi Huang,3 Yingqing Feng,1 Songtao Tang4 1Department of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, 510080, People’s Republic of China; 2The Second School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China; 3Guangdong Provincial People’s Hospital, School of Medicine, South China University of Technology, Guangzhou, People’s Republic of China; 4Department of Cardiology, Community Health Center of Liaobu Town, Dongguan, 523400, Guangdong, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Songtao TangDepartment of Cardiology, Community Health Center of Liaobu Town, Dongguan, 523400, Guangdong, People’s Republic of ChinaEmail 3038384760@qq.comYingqing FengDepartment of Cardiology, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, 106 2nd Zhongshan Road, Yuexiu District, Guangzhou, 510080, People’s Republic of ChinaEmail fengyingqing@gdph.org.cnBackground: Vascular overload index (VOI) is a marker of arterial stiffness and arteriolar resistance, which predicts the increasing risks of cardiovascular and cerebrovascular disease. This study aimed to evaluate the association between VOI and new-onset ischemic stroke in an elderly population with hypertension.Methods: This retrospective cohort study included 3315 hypertensive participants aged 60 years or more. Ischemic stroke was diagnosed according to cranial computed tomography, magnetic resonance imaging of the brain or cerebrovascular angiography. The calculation of VOI was based on systolic and diastolic blood pressure. VOI was divided by quartiles (< 7.88 mmHg, 7.88– 16.10 mmHg, 16.10– 27.14 mmHg, ≥ 27.14 mmHg) and evaluated the association with new-onset ischemic stroke by multivariable Cox regression models.Results: A total of 3315 participants (55.5% female) aged 71.4± 7.20 years were included in the analysis. The median follow-up period was 5.5 years, and 206 participants reached the endpoint, new-onset ischemic stroke. With per standard deviation increment in VOI, the risks of new-onset ischemic stroke increased in non-adjusted model (Hazard ratio [HR], 1.11; 95% confidence interval [CI]: 1.03– 1.22; p = 0.001), adjusted model (HR, 1.11; 95% CI: 1.04– 1.22; p = 0.003) and fully-adjusted model (HR, 1.15; 95% CI: 1.08– 1.26; p< 0.001), respectively. In multivariate fully adjusted model, the risks of ischemic stroke increased in higher quartiles in comparison to the first quartiles (p for trend < 0.001).Conclusion: In an elderly hypertensive population, VOI is significantly associated with the incidence of new-onset ischemic stroke. Elevated VOI is the cardiovascular risk factor and increases the probability of new-onset ischemic stroke.Keywords: vascular overload index, ischemic stroke, hypertension, elderly population, blood vessel
format	article
author	Yu Y Huang Y Liu L Liu XC Tan Q Chen C Huang J Feng Y Tang S
author_facet	Yu Y Huang Y Liu L Liu XC Tan Q Chen C Huang J Feng Y Tang S
author_sort	Yu Y
title	Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension
title_short	Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension
title_full	Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension
title_fullStr	Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension
title_full_unstemmed	Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension
title_sort	association between vascular overload index and new-onset ischemic stroke in elderly population with hypertension
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/948e3f3f5998415d842fb8a197d1245f
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Association Between Vascular Overload Index and New-Onset Ischemic Stroke in Elderly Population with Hypertension

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