In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells

Artemisia is one of the largest genera of the family Asteraceae or Compositae, consisting of 500 species. Some Artemisia species, such as Artemisia afra, A. sacrorum, and A. annua, have been widely used as traditional medicine to treat inflammatory and malarial diseases. However, the biological acti...

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Autores principales:	Seong Hun Jeong, Jisu Kim, Hyeyoung Min
Formato:	article
Lenguaje:	EN
Publicado:	Taylor & Francis Group 2018
Materias:	inflammation artemisia montana cytokines nitric oxide synthase cyclooxygenase Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/948e5397997246c896023d4fd9c56373
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spelling	oai:doaj.org-article:948e5397997246c896023d4fd9c563732021-11-26T11:19:46ZIn vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells0954-01051465-344310.1080/09540105.2018.1439454https://doaj.org/article/948e5397997246c896023d4fd9c563732018-01-01T00:00:00Zhttp://dx.doi.org/10.1080/09540105.2018.1439454https://doaj.org/toc/0954-0105https://doaj.org/toc/1465-3443Artemisia is one of the largest genera of the family Asteraceae or Compositae, consisting of 500 species. Some Artemisia species, such as Artemisia afra, A. sacrorum, and A. annua, have been widely used as traditional medicine to treat inflammatory and malarial diseases. However, the biological activity of A. montana has not been broadly studied. Therefore, in this study, we investigated the anti-inflammatory activity of A. montana leaf extract (ALE) and its molecular mechanisms in lipopolysaccharide-activated RAW 264.7 cells. Non-cytotoxic concentrations of ALE significantly reduced the expression of inducible nitric oxide (NO) synthase and cyclooxygenase-2, resulting in the decrease in NO and prostaglandin E2. Moreover, ALE inhibited the production of tumour necrosis factor-α and interleukin-6. We also observed that ALE treatment repressed mitogen-activated kinase pathways by inhibiting the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, suggesting that ALE is a therapeutic candidate to treat inflammatory diseases.Seong Hun JeongJisu KimHyeyoung MinTaylor & Francis Grouparticleinflammationartemisia montanacytokinesnitric oxide synthasecyclooxygenaseAgriculture (General)S1-972Immunologic diseases. AllergyRC581-607ENFood and Agricultural Immunology, Vol 29, Iss 1, Pp 688-698 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	inflammation artemisia montana cytokines nitric oxide synthase cyclooxygenase Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607
spellingShingle	inflammation artemisia montana cytokines nitric oxide synthase cyclooxygenase Agriculture (General) S1-972 Immunologic diseases. Allergy RC581-607 Seong Hun Jeong Jisu Kim Hyeyoung Min In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells
description	Artemisia is one of the largest genera of the family Asteraceae or Compositae, consisting of 500 species. Some Artemisia species, such as Artemisia afra, A. sacrorum, and A. annua, have been widely used as traditional medicine to treat inflammatory and malarial diseases. However, the biological activity of A. montana has not been broadly studied. Therefore, in this study, we investigated the anti-inflammatory activity of A. montana leaf extract (ALE) and its molecular mechanisms in lipopolysaccharide-activated RAW 264.7 cells. Non-cytotoxic concentrations of ALE significantly reduced the expression of inducible nitric oxide (NO) synthase and cyclooxygenase-2, resulting in the decrease in NO and prostaglandin E2. Moreover, ALE inhibited the production of tumour necrosis factor-α and interleukin-6. We also observed that ALE treatment repressed mitogen-activated kinase pathways by inhibiting the phosphorylation of extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, suggesting that ALE is a therapeutic candidate to treat inflammatory diseases.
format	article
author	Seong Hun Jeong Jisu Kim Hyeyoung Min
author_facet	Seong Hun Jeong Jisu Kim Hyeyoung Min
author_sort	Seong Hun Jeong
title	In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells
title_short	In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells
title_full	In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells
title_fullStr	In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells
title_full_unstemmed	In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells
title_sort	in vitro anti-inflammatory activity of the artemisia montana leaf ethanol extract in macrophage raw 264.7 cells
publisher	Taylor & Francis Group
publishDate	2018
url	https://doaj.org/article/948e5397997246c896023d4fd9c56373
work_keys_str_mv	AT seonghunjeong invitroantiinflammatoryactivityoftheartemisiamontanaleafethanolextractinmacrophageraw2647cells AT jisukim invitroantiinflammatoryactivityoftheartemisiamontanaleafethanolextractinmacrophageraw2647cells AT hyeyoungmin invitroantiinflammatoryactivityoftheartemisiamontanaleafethanolextractinmacrophageraw2647cells
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In vitro anti-inflammatory activity of the Artemisia montana leaf ethanol extract in macrophage RAW 264.7 cells

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