Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics

Sensitive LC-MS/MS Methods for Amphotericin B Analysis in Cerebrospinal Fluid, Plasma, Plasma Ultrafiltrate, and Urine: Application to Clinical Pharmacokinetics

Neurocryptococcosis, a meningoencephalitis caused by Cryptococcus spp, is treated with amphotericin B (AmB) combined with fluconazole. The integrity of the brain-blood barrier and the composition of the cerebrospinal fluid (CSF) may change due to infectious and/or inflammatory diseases such as neuro...

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Autores principales: Leandro Francisco Pippa, Maria Paula Marques, Anna Christina Tojal da Silva, Fernando Crivelenti Vilar, Tissiana Marques de Haes, Benedito Antônio Lopes da Fonseca, Roberto Martinez, Eduardo Barbosa Coelho, Lauro Wichert-Ana, Vera Lucia Lanchote
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
Materias:
amphotericin B
plasma
unbound fraction
urine
cerebrospinal fluid
LC-MS/MS
Chemistry
QD1-999
Acceso en línea:https://doaj.org/article/948f2159669748fc9ead71c9e2a891ea
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