The two faces of pannexins: new roles in inflammation and repair

Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs San Diego Healthcare System, San Diego, CA,...

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Autores principales:	Makarenkova HP, Shah SB, Shestopalov VI
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Pannexin Panx1 ATP purinergic signaling inflammation regeneration. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/94917afa050442d397c66927155c4589
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spelling	oai:doaj.org-article:94917afa050442d397c66927155c45892021-12-02T09:50:51ZThe two faces of pannexins: new roles in inflammation and repair1178-7031https://doaj.org/article/94917afa050442d397c66927155c45892018-06-01T00:00:00Zhttps://www.dovepress.com/the-two-faces-of-pannexins-new-roles-in-inflammation-and-repair-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs San Diego Healthcare System, San Diego, CA, 4Bascom Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA; 5Vavilov Institute for General Genetics, Russian Academy of Sciences, 6Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia Abstract: Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An increasing body of literature on pannexins suggests that these channels play dual and sometimes contradictory roles, contributing to normal cell function, as well as to the pathological progression of disease. In this review, we summarize our understanding of pannexin “protective” and “harmful” functions in inflammation, regeneration and mechanical signaling. We also suggest a possible basis for pannexin’s dual roles, related to extracellular ATP and K+ levels and the activation of various types of P2 receptors that are associated with pannexin. Finally, we speculate upon therapeutic strategies related to pannexin using eyes, lacrimal glands, and peripheral nerves as examples of interesting therapeutic targets. Keywords: pannexin, Panx1, ATP, purinergic signaling, inflammation, regenerationMakarenkova HPShah SBShestopalov VIDove Medical PressarticlePannexinPanx1ATPpurinergic signalinginflammationregeneration.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 11, Pp 273-288 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pannexin Panx1 ATP purinergic signaling inflammation regeneration. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	Pannexin Panx1 ATP purinergic signaling inflammation regeneration. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Makarenkova HP Shah SB Shestopalov VI The two faces of pannexins: new roles in inflammation and repair
description	Helen P Makarenkova,1 Sameer B Shah,2,3 Valery I Shestopalov4–6 1Department of Molecular Medicine, Scripps Research Institute, 2Departments of Orthopaedic Surgery and Bioengineering, University of California, 3Research Division, Veterans Affairs San Diego Healthcare System, San Diego, CA, 4Bascom Eye Institute, Department of Ophthalmology, University of Miami, Miami, FL, USA; 5Vavilov Institute for General Genetics, Russian Academy of Sciences, 6Kharkevich Institute for Information Transmission Problems, Russian Academy of Sciences, Moscow, Russia Abstract: Pannexins belong to a family of ATP-release channels expressed in almost all cell types. An increasing body of literature on pannexins suggests that these channels play dual and sometimes contradictory roles, contributing to normal cell function, as well as to the pathological progression of disease. In this review, we summarize our understanding of pannexin “protective” and “harmful” functions in inflammation, regeneration and mechanical signaling. We also suggest a possible basis for pannexin’s dual roles, related to extracellular ATP and K+ levels and the activation of various types of P2 receptors that are associated with pannexin. Finally, we speculate upon therapeutic strategies related to pannexin using eyes, lacrimal glands, and peripheral nerves as examples of interesting therapeutic targets. Keywords: pannexin, Panx1, ATP, purinergic signaling, inflammation, regeneration
format	article
author	Makarenkova HP Shah SB Shestopalov VI
author_facet	Makarenkova HP Shah SB Shestopalov VI
author_sort	Makarenkova HP
title	The two faces of pannexins: new roles in inflammation and repair
title_short	The two faces of pannexins: new roles in inflammation and repair
title_full	The two faces of pannexins: new roles in inflammation and repair
title_fullStr	The two faces of pannexins: new roles in inflammation and repair
title_full_unstemmed	The two faces of pannexins: new roles in inflammation and repair
title_sort	two faces of pannexins: new roles in inflammation and repair
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/94917afa050442d397c66927155c4589
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The two faces of pannexins: new roles in inflammation and repair

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