Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda

Background. Holoprosencephaly (HPE) is a rare cerebrofacial abnormality resulting from the complete or partial failure of the diverticulation and cleavage of the primitive forebrain. It has an incidence at birth of 1:16000. Case Presentation. We report a case of a 2600 g newborn female delivered by...

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Autores principales:	Franck Katembo Sikakulya, Sonye Magugu Kiyaka, Robert Masereka, Robinson Ssebuufu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/949664b4bca84aa7b033e5d735f4994b
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spelling	oai:doaj.org-article:949664b4bca84aa7b033e5d735f4994b2021-11-08T02:35:35ZAlobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda2090-677310.1155/2021/7282283https://doaj.org/article/949664b4bca84aa7b033e5d735f4994b2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7282283https://doaj.org/toc/2090-6773Background. Holoprosencephaly (HPE) is a rare cerebrofacial abnormality resulting from the complete or partial failure of the diverticulation and cleavage of the primitive forebrain. It has an incidence at birth of 1:16000. Case Presentation. We report a case of a 2600 g newborn female delivered by an HIV-infected mother in whom an antenatal ultrasound scan at 34 weeks’ gestation reported features of fetal alobar holoprosencephaly. The neonate was born with cebocephaly, a monkey-like head, and did not survive for more than 30 minutes following delivery by caesarian section despite oxygen therapy. Conclusion. Alobar HPE with cebocephaly remains incompatible with life. In this resource-limited setting, the diagnosis was made clinically, and only an ultrasound scan was performed to confirm the diagnosis. Chromosomal analysis could have given more information.Franck Katembo SikakulyaSonye Magugu KiyakaRobert MaserekaRobinson SsebuufuHindawi LimitedarticleOtorhinolaryngologyRF1-547ENCase Reports in Otolaryngology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Otorhinolaryngology RF1-547
spellingShingle	Otorhinolaryngology RF1-547 Franck Katembo Sikakulya Sonye Magugu Kiyaka Robert Masereka Robinson Ssebuufu Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda
description	Background. Holoprosencephaly (HPE) is a rare cerebrofacial abnormality resulting from the complete or partial failure of the diverticulation and cleavage of the primitive forebrain. It has an incidence at birth of 1:16000. Case Presentation. We report a case of a 2600 g newborn female delivered by an HIV-infected mother in whom an antenatal ultrasound scan at 34 weeks’ gestation reported features of fetal alobar holoprosencephaly. The neonate was born with cebocephaly, a monkey-like head, and did not survive for more than 30 minutes following delivery by caesarian section despite oxygen therapy. Conclusion. Alobar HPE with cebocephaly remains incompatible with life. In this resource-limited setting, the diagnosis was made clinically, and only an ultrasound scan was performed to confirm the diagnosis. Chromosomal analysis could have given more information.
format	article
author	Franck Katembo Sikakulya Sonye Magugu Kiyaka Robert Masereka Robinson Ssebuufu
author_facet	Franck Katembo Sikakulya Sonye Magugu Kiyaka Robert Masereka Robinson Ssebuufu
author_sort	Franck Katembo Sikakulya
title	Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda
title_short	Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda
title_full	Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda
title_fullStr	Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda
title_full_unstemmed	Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda
title_sort	alobar holoprosencephaly with cebocephaly in a neonate born to an hiv-positive mother in eastern uganda
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/949664b4bca84aa7b033e5d735f4994b
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Alobar Holoprosencephaly with Cebocephaly in a Neonate Born to an HIV-Positive Mother in Eastern Uganda

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