The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review
Introduction: Aspirin has justifiably been called the first miracle drug. In this article, we highlight the history of Aspirin, a novel mechanism of action, and its use in cardiovascular and other diseases. Also included is a brief statement of emerging new applications. Objective: We highlight pri...
Guardado en:
| Autores principales: | , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Emergency Department of Hospital San Pedro (Logroño, Spain)
2020
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/9498a08eaf7d46e89ea721b6111bea8b |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:9498a08eaf7d46e89ea721b6111bea8b |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:9498a08eaf7d46e89ea721b6111bea8b2021-12-02T19:15:08ZThe Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review10.5281/zenodo.39705192695-5075https://doaj.org/article/9498a08eaf7d46e89ea721b6111bea8b2020-08-01T00:00:00Zhttps://doi.org/10.5281/zenodo.3970519https://doaj.org/toc/2695-5075Introduction: Aspirin has justifiably been called the first miracle drug. In this article, we highlight the history of Aspirin, a novel mechanism of action, and its use in cardiovascular and other diseases. Also included is a brief statement of emerging new applications. Objective: We highlight principal mechanisms by which Aspirin inhibits acute inflammation and alters platelet-biology; therefore, hypothesized that Aspirin might prove highly beneficial as a novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID -19 patients. The communiqué also suggests possible strategies for maximizing the gain of Aspirin as a wonder-drug of the future. Discussion: Interestingly, some fascinating studies demonstrated Aspirin's superior benefits with dangerous side effects. Aspirin inhibits COX-1 (cyclooxygenase-1). Its impact on COX-2 is more delicate because it “turns off” COX-2's production of prostaglandins but “switches on” the enzymatic ability to produce novel protective lipid mediators. The established mechanism of action of Aspirin is the inhibition of prostaglandin synthesis. However, further evidence showed that aspirin-elicited nitric oxide exerts anti-inflammatory effects in the microcirculation by inhibiting leukocyte– endothelium interactions. Interestingly, aspirin-triggered lipoxin formation may provide a novel mechanism underlying Aspirin's clinical benefits. Interestingly, Aspirin reduces the risk of a cardiovascular event by about 30 percent. Also, Aspirin has been associated with a reduced risk of colorectal cancer, and possibly a few other digestive tract cancers. Conclusion: The current emerging interest is to conduct further study to provide evidence for Aspirin as the novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID-19 patients. Besides, the most wanted is The RECOVERY II (Randomized Evaluation of COVID-19 Therapy II) trial to be established as a randomized clinical trial to test the effectiveness of low-dose Aspirin as an anti-inflammatory and antithrombotic treatment in COVID-19 patients.Bamidele Johnson AlegbeleyeOke-Oghene Philomena AkpovesoAdewale James AlegbeleyeRana Kadhim MohammedEduardo Esteban-ZuberoEmergency Department of Hospital San Pedro (Logroño, Spain)articleaspirincovid-19systemic inflammatory responsecytokine stormnonsteroidal antiinflammatory drugssars-cov-2steroidsMedicine (General)R5-920ENIberoamerican Journal of Medicine, Vol 2, Iss 4, Pp 335-350 (2020) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
aspirin covid-19 systemic inflammatory response cytokine storm nonsteroidal antiinflammatory drugs sars-cov-2 steroids Medicine (General) R5-920 |
| spellingShingle |
aspirin covid-19 systemic inflammatory response cytokine storm nonsteroidal antiinflammatory drugs sars-cov-2 steroids Medicine (General) R5-920 Bamidele Johnson Alegbeleye Oke-Oghene Philomena Akpoveso Adewale James Alegbeleye Rana Kadhim Mohammed Eduardo Esteban-Zubero The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review |
| description |
Introduction: Aspirin has justifiably been called the first miracle drug. In this article, we highlight the history of Aspirin, a novel mechanism of action, and its use in cardiovascular and other diseases. Also included is a brief statement of emerging new applications.
Objective: We highlight principal mechanisms by which Aspirin inhibits acute inflammation and alters platelet-biology; therefore, hypothesized that Aspirin might prove highly beneficial as a novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID -19 patients. The communiqué also suggests possible strategies for maximizing the gain of Aspirin as a wonder-drug of the future.
Discussion: Interestingly, some fascinating studies demonstrated Aspirin's superior benefits with dangerous side effects. Aspirin inhibits COX-1 (cyclooxygenase-1). Its impact on COX-2 is more delicate because it “turns off” COX-2's production of prostaglandins but “switches on” the enzymatic ability to produce novel protective lipid mediators. The established mechanism of action of Aspirin is the inhibition of prostaglandin synthesis. However, further evidence showed that aspirin-elicited nitric oxide exerts anti-inflammatory effects in the microcirculation by inhibiting leukocyte– endothelium interactions. Interestingly, aspirin-triggered lipoxin formation may provide a novel mechanism underlying Aspirin's clinical benefits. Interestingly, Aspirin reduces the risk of a cardiovascular event by about 30 percent. Also, Aspirin has been associated with a reduced risk of colorectal cancer, and possibly a few other digestive tract cancers.
Conclusion: The current emerging interest is to conduct further study to provide evidence for Aspirin as the novel therapeutic drug for combating severe acute inflammation and thrombosis associated with the cytokine storm in COVID-19 patients. Besides, the most wanted is The RECOVERY II (Randomized Evaluation of COVID-19 Therapy II) trial to be established as a randomized clinical trial to test the effectiveness of low-dose Aspirin as an anti-inflammatory and antithrombotic treatment in COVID-19 patients. |
| format |
article |
| author |
Bamidele Johnson Alegbeleye Oke-Oghene Philomena Akpoveso Adewale James Alegbeleye Rana Kadhim Mohammed Eduardo Esteban-Zubero |
| author_facet |
Bamidele Johnson Alegbeleye Oke-Oghene Philomena Akpoveso Adewale James Alegbeleye Rana Kadhim Mohammed Eduardo Esteban-Zubero |
| author_sort |
Bamidele Johnson Alegbeleye |
| title |
The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review |
| title_short |
The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review |
| title_full |
The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review |
| title_fullStr |
The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review |
| title_full_unstemmed |
The Novel Aspirin as Breakthrough Drug for COVID-19: A Narrative Review |
| title_sort |
novel aspirin as breakthrough drug for covid-19: a narrative review |
| publisher |
Emergency Department of Hospital San Pedro (Logroño, Spain) |
| publishDate |
2020 |
| url |
https://doaj.org/article/9498a08eaf7d46e89ea721b6111bea8b |
| work_keys_str_mv |
AT bamidelejohnsonalegbeleye thenovelaspirinasbreakthroughdrugforcovid19anarrativereview AT okeoghenephilomenaakpoveso thenovelaspirinasbreakthroughdrugforcovid19anarrativereview AT adewalejamesalegbeleye thenovelaspirinasbreakthroughdrugforcovid19anarrativereview AT ranakadhimmohammed thenovelaspirinasbreakthroughdrugforcovid19anarrativereview AT eduardoestebanzubero thenovelaspirinasbreakthroughdrugforcovid19anarrativereview AT bamidelejohnsonalegbeleye novelaspirinasbreakthroughdrugforcovid19anarrativereview AT okeoghenephilomenaakpoveso novelaspirinasbreakthroughdrugforcovid19anarrativereview AT adewalejamesalegbeleye novelaspirinasbreakthroughdrugforcovid19anarrativereview AT ranakadhimmohammed novelaspirinasbreakthroughdrugforcovid19anarrativereview AT eduardoestebanzubero novelaspirinasbreakthroughdrugforcovid19anarrativereview |
| _version_ |
1718376986343112704 |