Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry

Due to the raising number of TAVR implantations (transcatheter aortic valve replacement), tests for durability and prevention of associated diseases are becoming increasingly important. Not only the anatomy but also the positioning of the TAVR is decisive for its clinical performance. A misalignment...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Borowski Finja, Oldenburg Jan, Pfensig Sylvia, Kaule Sebastian, Siewert Stefan, Schmitz Klaus-Peter, Stiehm Michael
Formato:	article
Lenguaje:	EN
Publicado:	De Gruyter 2020
Materias:	transcatheter aortic valve implantation haemodynamics particle image velocimetry Medicine R
Acceso en línea:	https://doaj.org/article/949e0bd748124da4bbbb7b9719539fcf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:949e0bd748124da4bbbb7b9719539fcf
record_format	dspace
spelling	oai:doaj.org-article:949e0bd748124da4bbbb7b9719539fcf2021-12-05T14:10:42ZInvestigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry2364-550410.1515/cdbme-2020-3041https://doaj.org/article/949e0bd748124da4bbbb7b9719539fcf2020-09-01T00:00:00Zhttps://doi.org/10.1515/cdbme-2020-3041https://doaj.org/toc/2364-5504Due to the raising number of TAVR implantations (transcatheter aortic valve replacement), tests for durability and prevention of associated diseases are becoming increasingly important. Not only the anatomy but also the positioning of the TAVR is decisive for its clinical performance. A misalignment in the circumferential direction can influence the flow in the sinus and thus inhibit the blood supply of the coronary arteries and influence the thrombosis potential. Therefore, the modification of the flow field is investigated in this study. For the characterization of the flow fields the measuring method of digital particle image velocimetry is used. A hydraulic circulation model is used to generate physiological flow and pressure conditions. Additionally, an aortic root model with Sinus Valsalvae, which represents the implantation environment, was developed. A prototype of a TAVR was implanted aligned to the commissure lines of the native valve leaflets on the one hand, and misaligned by 60 degree to the commissure of the native valves on the other hand. By determining the velocity vector fields, it could be shown that implantation of the TAVR with a commissureal misalignment influences the flow around the leaflets. A comparison of the flow fields shows that different recirculation areas occur. This is also indicated by a comparison of the mean velocities in the sinus and the observed shear rates. The influence of the altered flow field on the thrombosis and hemolysis potential should be investigated in future studies.Borowski FinjaOldenburg JanPfensig SylviaKaule SebastianSiewert StefanSchmitz Klaus-PeterStiehm MichaelDe Gruyterarticletranscatheter aortic valve implantationhaemodynamicsparticle image velocimetryMedicineRENCurrent Directions in Biomedical Engineering, Vol 6, Iss 3, Pp 159-163 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	transcatheter aortic valve implantation haemodynamics particle image velocimetry Medicine R
spellingShingle	transcatheter aortic valve implantation haemodynamics particle image velocimetry Medicine R Borowski Finja Oldenburg Jan Pfensig Sylvia Kaule Sebastian Siewert Stefan Schmitz Klaus-Peter Stiehm Michael Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry
description	Due to the raising number of TAVR implantations (transcatheter aortic valve replacement), tests for durability and prevention of associated diseases are becoming increasingly important. Not only the anatomy but also the positioning of the TAVR is decisive for its clinical performance. A misalignment in the circumferential direction can influence the flow in the sinus and thus inhibit the blood supply of the coronary arteries and influence the thrombosis potential. Therefore, the modification of the flow field is investigated in this study. For the characterization of the flow fields the measuring method of digital particle image velocimetry is used. A hydraulic circulation model is used to generate physiological flow and pressure conditions. Additionally, an aortic root model with Sinus Valsalvae, which represents the implantation environment, was developed. A prototype of a TAVR was implanted aligned to the commissure lines of the native valve leaflets on the one hand, and misaligned by 60 degree to the commissure of the native valves on the other hand. By determining the velocity vector fields, it could be shown that implantation of the TAVR with a commissureal misalignment influences the flow around the leaflets. A comparison of the flow fields shows that different recirculation areas occur. This is also indicated by a comparison of the mean velocities in the sinus and the observed shear rates. The influence of the altered flow field on the thrombosis and hemolysis potential should be investigated in future studies.
format	article
author	Borowski Finja Oldenburg Jan Pfensig Sylvia Kaule Sebastian Siewert Stefan Schmitz Klaus-Peter Stiehm Michael
author_facet	Borowski Finja Oldenburg Jan Pfensig Sylvia Kaule Sebastian Siewert Stefan Schmitz Klaus-Peter Stiehm Michael
author_sort	Borowski Finja
title	Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry
title_short	Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry
title_full	Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry
title_fullStr	Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry
title_full_unstemmed	Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry
title_sort	investigations of flow alteration of commissural misalignment of tavr using particle image velocimetry
publisher	De Gruyter
publishDate	2020
url	https://doaj.org/article/949e0bd748124da4bbbb7b9719539fcf
work_keys_str_mv	AT borowskifinja investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry AT oldenburgjan investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry AT pfensigsylvia investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry AT kaulesebastian investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry AT siewertstefan investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry AT schmitzklauspeter investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry AT stiehmmichael investigationsofflowalterationofcommissuralmisalignmentoftavrusingparticleimagevelocimetry
_version_	1718371796936294400

Investigations of flow alteration of commissural misalignment of TAVR using Particle Image Velocimetry

Ejemplares similares