Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

Arousal levels perpetually rise and fall spontaneously. How markers of arousal—pupil size and frequency content of brain activity—relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and...

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Autores principales:	Ella Podvalny, Leana E King, Biyu J He
Formato:	article
Lenguaje:	EN
Publicado:	eLife Sciences Publications Ltd 2021
Materias:	spontaneous activity electrophysiological arousal pupil-linked arousal perceptual decision-making signal detection theory Medicine R Science Q Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/949ea3e0c86c43449831ee41a2aa73d8
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spelling	oai:doaj.org-article:949ea3e0c86c43449831ee41a2aa73d82021-11-25T10:23:29ZSpectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human10.7554/eLife.682652050-084Xe68265https://doaj.org/article/949ea3e0c86c43449831ee41a2aa73d82021-08-01T00:00:00Zhttps://elifesciences.org/articles/68265https://doaj.org/toc/2050-084XArousal levels perpetually rise and fall spontaneously. How markers of arousal—pupil size and frequency content of brain activity—relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and during a visual perceptual decision-making task. Spontaneously varying pupil size correlates with power of brain activity in most frequency bands across large-scale resting state cortical networks. Pupil size recorded at prestimulus baseline correlates with subsequent shifts in detection bias (c) and sensitivity (d’). When dissociated from pupil-linked state, prestimulus spectral power of resting state networks still predicts perceptual behavior. Fast spontaneous pupil constriction and dilation correlate with large-scale brain activity as well but not perceptual behavior. Our results illuminate the relation between central and peripheral arousal markers and their respective roles in human perceptual decision-making.Ella PodvalnyLeana E KingBiyu J HeeLife Sciences Publications Ltdarticlespontaneous activityelectrophysiological arousalpupil-linked arousalperceptual decision-makingsignal detection theoryMedicineRScienceQBiology (General)QH301-705.5ENeLife, Vol 10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	spontaneous activity electrophysiological arousal pupil-linked arousal perceptual decision-making signal detection theory Medicine R Science Q Biology (General) QH301-705.5
spellingShingle	spontaneous activity electrophysiological arousal pupil-linked arousal perceptual decision-making signal detection theory Medicine R Science Q Biology (General) QH301-705.5 Ella Podvalny Leana E King Biyu J He Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
description	Arousal levels perpetually rise and fall spontaneously. How markers of arousal—pupil size and frequency content of brain activity—relate to each other and influence behavior in humans is poorly understood. We simultaneously monitored magnetoencephalography and pupil in healthy volunteers at rest and during a visual perceptual decision-making task. Spontaneously varying pupil size correlates with power of brain activity in most frequency bands across large-scale resting state cortical networks. Pupil size recorded at prestimulus baseline correlates with subsequent shifts in detection bias (c) and sensitivity (d’). When dissociated from pupil-linked state, prestimulus spectral power of resting state networks still predicts perceptual behavior. Fast spontaneous pupil constriction and dilation correlate with large-scale brain activity as well but not perceptual behavior. Our results illuminate the relation between central and peripheral arousal markers and their respective roles in human perceptual decision-making.
format	article
author	Ella Podvalny Leana E King Biyu J He
author_facet	Ella Podvalny Leana E King Biyu J He
author_sort	Ella Podvalny
title	Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
title_short	Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
title_full	Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
title_fullStr	Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
title_full_unstemmed	Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
title_sort	spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human
publisher	eLife Sciences Publications Ltd
publishDate	2021
url	https://doaj.org/article/949ea3e0c86c43449831ee41a2aa73d8
work_keys_str_mv	AT ellapodvalny spectralsignatureandbehavioralconsequenceofspontaneousshiftsofpupillinkedarousalinhuman AT leanaeking spectralsignatureandbehavioralconsequenceofspontaneousshiftsofpupillinkedarousalinhuman AT biyujhe spectralsignatureandbehavioralconsequenceofspontaneousshiftsofpupillinkedarousalinhuman
_version_	1718413572195745792

Spectral signature and behavioral consequence of spontaneous shifts of pupil-linked arousal in human

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