α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins

The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders. Following cDNA library screening, the authors identify anti-apoptotic, Bcl-2 family proteins as enhancers of α7 nA...

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Autores principales:	G. Brent Dawe, Hong Yu, Shenyan Gu, Alissa N. Blackler, Jose A. Matta, Edward R. Siuda, Elizabeth B. Rex, David S. Bredt
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94a386d702d14777ad23a1ac9956e5a0
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spelling	oai:doaj.org-article:94a386d702d14777ad23a1ac9956e5a02021-12-02T17:01:58Zα7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins10.1038/s41467-019-10723-x2041-1723https://doaj.org/article/94a386d702d14777ad23a1ac9956e5a02019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10723-xhttps://doaj.org/toc/2041-1723The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders. Following cDNA library screening, the authors identify anti-apoptotic, Bcl-2 family proteins as enhancers of α7 nAChR assembly, acting through an intracellular BH3-like domain during receptor biogenesis in the endoplasmic reticulum.G. Brent DaweHong YuShenyan GuAlissa N. BlacklerJose A. MattaEdward R. SiudaElizabeth B. RexDavid S. BredtNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q G. Brent Dawe Hong Yu Shenyan Gu Alissa N. Blackler Jose A. Matta Edward R. Siuda Elizabeth B. Rex David S. Bredt α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
description	The α7 nicotinic acetylcholine receptor (nAChR) plays a major role in shaping the activity of neuronal circuits and contributes to the pathophysiology of several neurological disorders. Following cDNA library screening, the authors identify anti-apoptotic, Bcl-2 family proteins as enhancers of α7 nAChR assembly, acting through an intracellular BH3-like domain during receptor biogenesis in the endoplasmic reticulum.
format	article
author	G. Brent Dawe Hong Yu Shenyan Gu Alissa N. Blackler Jose A. Matta Edward R. Siuda Elizabeth B. Rex David S. Bredt
author_facet	G. Brent Dawe Hong Yu Shenyan Gu Alissa N. Blackler Jose A. Matta Edward R. Siuda Elizabeth B. Rex David S. Bredt
author_sort	G. Brent Dawe
title	α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
title_short	α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
title_full	α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
title_fullStr	α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
title_full_unstemmed	α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins
title_sort	α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic bcl-2 proteins
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/94a386d702d14777ad23a1ac9956e5a0
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α7 nicotinic acetylcholine receptor upregulation by anti-apoptotic Bcl-2 proteins

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