Backbone Conformation Shifts in X-ray Structures of Human Acetylcholinesterase upon Covalent Organophosphate Inhibition
Conformations of Cα backbones in X-ray structures of most organophosphate (OP)-inhibited human acetylcholinesterases (hAChEs) have been previously shown to be similar to that of the native hAChE. One of the exceptions is the structure of the diethylphosphoryl-hAChE conjugate, where stabilization of...
Guardado en:
Autores principales: | Stephanie Luedtke, Celine Bojo, Yunshen Li, Emilio Luna, Bianca Pomar, Zoran Radić |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
MDPI AG
2021
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Acceso en línea: | https://doaj.org/article/94a5acd9271e4ecba05bfc956d24d0e3 |
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