Therapeutic vaccines for allergic disease

Abstract Allergic diseases are highly prevalent worldwide and affect all age groups, contributing to a high personal and socioeconomic burden. Treatment with an “allergy vaccine” or allergen immunotherapy aims to provide long-lasting benefits by inducing unresponsiveness to the relevant antigen. The...

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Autores principales:	Danuta Gutowska-Owsiak, Graham S. Ogg
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/94a5bc1adc39429493086bc6f92391b2
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spelling	oai:doaj.org-article:94a5bc1adc39429493086bc6f92391b22021-12-02T15:18:52ZTherapeutic vaccines for allergic disease10.1038/s41541-017-0014-82059-0105https://doaj.org/article/94a5bc1adc39429493086bc6f92391b22017-05-01T00:00:00Zhttps://doi.org/10.1038/s41541-017-0014-8https://doaj.org/toc/2059-0105Abstract Allergic diseases are highly prevalent worldwide and affect all age groups, contributing to a high personal and socioeconomic burden. Treatment with an “allergy vaccine” or allergen immunotherapy aims to provide long-lasting benefits by inducing unresponsiveness to the relevant antigen. The consequences of the therapy are considered disease modifying and range from dampening of the immediate immune responses to the reduction of secondary tissue remodeling. Furthermore, allergen immunotherapy interventions have a potential to slow or cease the development of additional allergic manifestations with a long-term overall effect on morbidity and quality of life. Here, we review proposed mechanisms underlying the therapeutic effects of immunotherapy for allergic diseases. Further, we discuss both standard and novel approaches and possible future directions in the development of allergen immunotherapy.Danuta Gutowska-OwsiakGraham S. OggNature PortfolioarticleImmunologic diseases. AllergyRC581-607Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Vaccines, Vol 2, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Immunologic diseases. Allergy RC581-607 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Danuta Gutowska-Owsiak Graham S. Ogg Therapeutic vaccines for allergic disease
description	Abstract Allergic diseases are highly prevalent worldwide and affect all age groups, contributing to a high personal and socioeconomic burden. Treatment with an “allergy vaccine” or allergen immunotherapy aims to provide long-lasting benefits by inducing unresponsiveness to the relevant antigen. The consequences of the therapy are considered disease modifying and range from dampening of the immediate immune responses to the reduction of secondary tissue remodeling. Furthermore, allergen immunotherapy interventions have a potential to slow or cease the development of additional allergic manifestations with a long-term overall effect on morbidity and quality of life. Here, we review proposed mechanisms underlying the therapeutic effects of immunotherapy for allergic diseases. Further, we discuss both standard and novel approaches and possible future directions in the development of allergen immunotherapy.
format	article
author	Danuta Gutowska-Owsiak Graham S. Ogg
author_facet	Danuta Gutowska-Owsiak Graham S. Ogg
author_sort	Danuta Gutowska-Owsiak
title	Therapeutic vaccines for allergic disease
title_short	Therapeutic vaccines for allergic disease
title_full	Therapeutic vaccines for allergic disease
title_fullStr	Therapeutic vaccines for allergic disease
title_full_unstemmed	Therapeutic vaccines for allergic disease
title_sort	therapeutic vaccines for allergic disease
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94a5bc1adc39429493086bc6f92391b2
work_keys_str_mv	AT danutagutowskaowsiak therapeuticvaccinesforallergicdisease AT grahamsogg therapeuticvaccinesforallergicdisease
_version_	1718387460374790144

Therapeutic vaccines for allergic disease

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