Towards the application of Tc toxins as a universal protein translocation system

Tc toxins are a major class of bacterial toxin translocation systems that inject toxic enzymes into target cells. Here the authors present functional and structural data showing that the toxic enzyme can be replaced by other small proteins and identify prerequisites required for successful transloca...

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Autores principales:	Daniel Roderer, Evelyn Schubert, Oleg Sitsel, Stefan Raunser
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94a616e7e02c4385bfa17c5b619689df
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spelling	oai:doaj.org-article:94a616e7e02c4385bfa17c5b619689df2021-12-02T14:38:42ZTowards the application of Tc toxins as a universal protein translocation system10.1038/s41467-019-13253-82041-1723https://doaj.org/article/94a616e7e02c4385bfa17c5b619689df2019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13253-8https://doaj.org/toc/2041-1723Tc toxins are a major class of bacterial toxin translocation systems that inject toxic enzymes into target cells. Here the authors present functional and structural data showing that the toxic enzyme can be replaced by other small proteins and identify prerequisites required for successful translocation, which could facilitate the development of functional Tc-based protein injection devices.Daniel RodererEvelyn SchubertOleg SitselStefan RaunserNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Daniel Roderer Evelyn Schubert Oleg Sitsel Stefan Raunser Towards the application of Tc toxins as a universal protein translocation system
description	Tc toxins are a major class of bacterial toxin translocation systems that inject toxic enzymes into target cells. Here the authors present functional and structural data showing that the toxic enzyme can be replaced by other small proteins and identify prerequisites required for successful translocation, which could facilitate the development of functional Tc-based protein injection devices.
format	article
author	Daniel Roderer Evelyn Schubert Oleg Sitsel Stefan Raunser
author_facet	Daniel Roderer Evelyn Schubert Oleg Sitsel Stefan Raunser
author_sort	Daniel Roderer
title	Towards the application of Tc toxins as a universal protein translocation system
title_short	Towards the application of Tc toxins as a universal protein translocation system
title_full	Towards the application of Tc toxins as a universal protein translocation system
title_fullStr	Towards the application of Tc toxins as a universal protein translocation system
title_full_unstemmed	Towards the application of Tc toxins as a universal protein translocation system
title_sort	towards the application of tc toxins as a universal protein translocation system
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/94a616e7e02c4385bfa17c5b619689df
work_keys_str_mv	AT danielroderer towardstheapplicationoftctoxinsasauniversalproteintranslocationsystem AT evelynschubert towardstheapplicationoftctoxinsasauniversalproteintranslocationsystem AT olegsitsel towardstheapplicationoftctoxinsasauniversalproteintranslocationsystem AT stefanraunser towardstheapplicationoftctoxinsasauniversalproteintranslocationsystem
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Towards the application of Tc toxins as a universal protein translocation system

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