Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate...

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Autores principales:	Vincenzo Bellizzi, Patrizia Calella, Juan Jesus Carrero, Denis Fouque
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2018
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/94a9e55ccf004c76b878a6cba2e55532
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spelling	oai:doaj.org-article:94a9e55ccf004c76b878a6cba2e555322021-12-02T17:30:51ZVery low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease2095-882X10.1016/j.cdtm.2018.01.003https://doaj.org/article/94a9e55ccf004c76b878a6cba2e555322018-03-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X18300021https://doaj.org/toc/2095-882XThe uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease. Keywords: Low-protein diet, Ketoanalogs, Renal failure, Chronic kidney diseaseVincenzo BellizziPatrizia CalellaJuan Jesus CarreroDenis FouqueKeAi Communications Co., Ltd.articleMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 4, Iss 1, Pp 45-50 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Vincenzo Bellizzi Patrizia Calella Juan Jesus Carrero Denis Fouque Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
description	The uremic syndrome is a metabolic disorder characterized by the impairment of renal handling of several solutes, the resulting accumulation of toxic products and the activation of some adaptive but detrimental mechanisms which all together contribute to the progression of renal damage. In moderate to advanced renal failure, the dietary manipulation of nutrients improves metabolic abnormalities and may contribute to delay the time of dialysis initiation. This commentary focuses on the physiopathological rationale and the clinical application of the very low-protein diet supplemented with ketoanalogs for the management of chronic kidney disease. Keywords: Low-protein diet, Ketoanalogs, Renal failure, Chronic kidney disease
format	article
author	Vincenzo Bellizzi Patrizia Calella Juan Jesus Carrero Denis Fouque
author_facet	Vincenzo Bellizzi Patrizia Calella Juan Jesus Carrero Denis Fouque
author_sort	Vincenzo Bellizzi
title	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_short	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_full	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_fullStr	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_full_unstemmed	Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease
title_sort	very low-protein diet to postpone renal failure: pathophysiology and clinical applications in chronic kidney disease
publisher	KeAi Communications Co., Ltd.
publishDate	2018
url	https://doaj.org/article/94a9e55ccf004c76b878a6cba2e55532
work_keys_str_mv	AT vincenzobellizzi verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease AT patriziacalella verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease AT juanjesuscarrero verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease AT denisfouque verylowproteindiettopostponerenalfailurepathophysiologyandclinicalapplicationsinchronickidneydisease
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Very low-protein diet to postpone renal failure: Pathophysiology and clinical applications in chronic kidney disease

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