Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection

Amyloid aggregation and fungal infection, especially amyloid beta (Aβ) peptide and Candida albicans are considered as two of the crucial pathogenic agents in Alzheimer's disease (AD). In this work, we propose an innovative treatment strategy for AD, targeting at not only Aβ aggregation but also...

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Autores principales:	Chaoren Yan, Chaoli Wang, Xu Shao, Qi Shu, Xiaoling Hu, Ping Guan, Yonggang Teng, Yuan Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Glycosylated carbon dots Epigallocatechin-3-gallate Amyloid-βpeptide Candida albicans Alzheimer's disease Medicine (General) R5-920 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/94aad36350f046099a9215474c69ab91
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spelling	oai:doaj.org-article:94aad36350f046099a9215474c69ab912021-11-30T04:17:32ZDual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection2590-006410.1016/j.mtbio.2021.100167https://doaj.org/article/94aad36350f046099a9215474c69ab912021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2590006421000752https://doaj.org/toc/2590-0064Amyloid aggregation and fungal infection, especially amyloid beta (Aβ) peptide and Candida albicans are considered as two of the crucial pathogenic agents in Alzheimer's disease (AD). In this work, we propose an innovative treatment strategy for AD, targeting at not only Aβ aggregation but also Candida albicans infection. Here, a high-performance nanomaterial, namely gCDs-E, have been prepared by self-assembled of glycosylated carbon dots (gCDs) and epigallocatechin-3-gallate (EGCG). Surprisingly, gCDs-E can not only suppress the fibrillation of Aβ and disaggregate Aβ fibrils, but also effectively inhibit the activity of Candida albicans. More importantly, the prepared gCDs-E can effectively cut down the cytotoxicity of amyloid aggregations, and the cell viability reached to 99.2%. In addition, the capability of the gCDs-E for blood brain barrier (BBB) penetration was also observed using a normal mice model. Above all, the gCDs-E greatly cleaned Aβ deposition and improved memory impairment in APP/PS1 transgenic AD model mice, confirming its potential as therapeutic agent for AD treatment.Chaoren YanChaoli WangXu ShaoQi ShuXiaoling HuPing GuanYonggang TengYuan ChengElsevierarticleGlycosylated carbon dotsEpigallocatechin-3-gallateAmyloid-βpeptideCandida albicansAlzheimer's diseaseMedicine (General)R5-920Biology (General)QH301-705.5ENMaterials Today Bio, Vol 12, Iss , Pp 100167- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Glycosylated carbon dots Epigallocatechin-3-gallate Amyloid-βpeptide Candida albicans Alzheimer's disease Medicine (General) R5-920 Biology (General) QH301-705.5
spellingShingle	Glycosylated carbon dots Epigallocatechin-3-gallate Amyloid-βpeptide Candida albicans Alzheimer's disease Medicine (General) R5-920 Biology (General) QH301-705.5 Chaoren Yan Chaoli Wang Xu Shao Qi Shu Xiaoling Hu Ping Guan Yonggang Teng Yuan Cheng Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection
description	Amyloid aggregation and fungal infection, especially amyloid beta (Aβ) peptide and Candida albicans are considered as two of the crucial pathogenic agents in Alzheimer's disease (AD). In this work, we propose an innovative treatment strategy for AD, targeting at not only Aβ aggregation but also Candida albicans infection. Here, a high-performance nanomaterial, namely gCDs-E, have been prepared by self-assembled of glycosylated carbon dots (gCDs) and epigallocatechin-3-gallate (EGCG). Surprisingly, gCDs-E can not only suppress the fibrillation of Aβ and disaggregate Aβ fibrils, but also effectively inhibit the activity of Candida albicans. More importantly, the prepared gCDs-E can effectively cut down the cytotoxicity of amyloid aggregations, and the cell viability reached to 99.2%. In addition, the capability of the gCDs-E for blood brain barrier (BBB) penetration was also observed using a normal mice model. Above all, the gCDs-E greatly cleaned Aβ deposition and improved memory impairment in APP/PS1 transgenic AD model mice, confirming its potential as therapeutic agent for AD treatment.
format	article
author	Chaoren Yan Chaoli Wang Xu Shao Qi Shu Xiaoling Hu Ping Guan Yonggang Teng Yuan Cheng
author_facet	Chaoren Yan Chaoli Wang Xu Shao Qi Shu Xiaoling Hu Ping Guan Yonggang Teng Yuan Cheng
author_sort	Chaoren Yan
title	Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection
title_short	Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection
title_full	Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection
title_fullStr	Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection
title_full_unstemmed	Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection
title_sort	dual-targeted carbon-dot-drugs nanoassemblies for modulating alzheimer's related amyloid-β aggregation and inhibiting fungal infection
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/94aad36350f046099a9215474c69ab91
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Dual-targeted carbon-dot-drugs nanoassemblies for modulating Alzheimer's related amyloid-β aggregation and inhibiting fungal infection

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