Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen

Abstract Comparison of several regimens of oral vitamin D including an individually calculated loading regimen with the aim of achieving serum values > 75 nmol/l. Interventional, randomized, 3-arm study in vitamin D-deficient outpatients. Participants were allocated to supplementation of 24,000 I...

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Autores principales:	Jean-Pierre Rothen, Jonas Rutishauser, Philipp N. Walter, Kurt E. Hersberger, Isabelle Arnet
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94ad3ba085c54a6a932e8423fc4e7e7b
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spelling	oai:doaj.org-article:94ad3ba085c54a6a932e8423fc4e7e7b2021-12-02T17:26:55ZVitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen10.1038/s41598-021-97417-x2045-2322https://doaj.org/article/94ad3ba085c54a6a932e8423fc4e7e7b2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97417-xhttps://doaj.org/toc/2045-2322Abstract Comparison of several regimens of oral vitamin D including an individually calculated loading regimen with the aim of achieving serum values > 75 nmol/l. Interventional, randomized, 3-arm study in vitamin D-deficient outpatients. Participants were allocated to supplementation of 24,000 IU vitamin D monthly over three months, using either a monthly drinking solution (Vi-De 3) or capsule (D3 VitaCaps), or an individualized loading regimen with the capsules taken weekly. For the loading regimen, the cumulative dose was calculated according to baseline 25-hydroxy-vitamin D (25(OH)D) serum value and body weight. Main inclusion criteria were age ≥ 18 years and 25(OH)D serum concentration < 50 nmol/l. The primary outcome was 25(OH)D serum concentration one week after treatment termination. Secondary endpoints were patient’s preferences and adverse events. Full datasets were obtained from 52 patients. Mean 25(OH)D values were statistically significant higher after a loading regimen compared to a monthly administration of 24,000 IU vitamin D (76.4 ± 15.8 vs 61.4 ± 10.8 nmol/l; p < 0.01). All patients treated with the loading regimen reached sufficient 25(OH)D values > 50 nmol/l. Serum 25(OH)D values > 75 nmol/l were observed more frequently in patients taking the loading regimen (47% vs 11% drinking solution vs 12% capsules). Vitamin D-related adverse effects did not occur in any treatment groups. Capsules were preferred by 88.5% of the patients. Compared to treatments with monthly intake of 24,000 IU vitamin D, the intake of an individually calculated weekly loading regimen was able to raise serum concentrations > 50 nmol/l in all cases within a safe range.Jean-Pierre RothenJonas RutishauserPhilipp N. WalterKurt E. HersbergerIsabelle ArnetNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jean-Pierre Rothen Jonas Rutishauser Philipp N. Walter Kurt E. Hersberger Isabelle Arnet Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
description	Abstract Comparison of several regimens of oral vitamin D including an individually calculated loading regimen with the aim of achieving serum values > 75 nmol/l. Interventional, randomized, 3-arm study in vitamin D-deficient outpatients. Participants were allocated to supplementation of 24,000 IU vitamin D monthly over three months, using either a monthly drinking solution (Vi-De 3) or capsule (D3 VitaCaps), or an individualized loading regimen with the capsules taken weekly. For the loading regimen, the cumulative dose was calculated according to baseline 25-hydroxy-vitamin D (25(OH)D) serum value and body weight. Main inclusion criteria were age ≥ 18 years and 25(OH)D serum concentration < 50 nmol/l. The primary outcome was 25(OH)D serum concentration one week after treatment termination. Secondary endpoints were patient’s preferences and adverse events. Full datasets were obtained from 52 patients. Mean 25(OH)D values were statistically significant higher after a loading regimen compared to a monthly administration of 24,000 IU vitamin D (76.4 ± 15.8 vs 61.4 ± 10.8 nmol/l; p < 0.01). All patients treated with the loading regimen reached sufficient 25(OH)D values > 50 nmol/l. Serum 25(OH)D values > 75 nmol/l were observed more frequently in patients taking the loading regimen (47% vs 11% drinking solution vs 12% capsules). Vitamin D-related adverse effects did not occur in any treatment groups. Capsules were preferred by 88.5% of the patients. Compared to treatments with monthly intake of 24,000 IU vitamin D, the intake of an individually calculated weekly loading regimen was able to raise serum concentrations > 50 nmol/l in all cases within a safe range.
format	article
author	Jean-Pierre Rothen Jonas Rutishauser Philipp N. Walter Kurt E. Hersberger Isabelle Arnet
author_facet	Jean-Pierre Rothen Jonas Rutishauser Philipp N. Walter Kurt E. Hersberger Isabelle Arnet
author_sort	Jean-Pierre Rothen
title	Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
title_short	Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
title_full	Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
title_fullStr	Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
title_full_unstemmed	Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen
title_sort	vitamin d oral intermittent treatment (do it) study, a randomized clinical trial with individual loading regimen
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/94ad3ba085c54a6a932e8423fc4e7e7b
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Vitamin D oral intermittent treatment (DO IT) study, a randomized clinical trial with individual loading regimen

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