Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

The dopamine transporter (DAT) has a crucial role in the regulation of neurotransmission. Here, the authors use super-resolution imaging to show that DAT clusters into cholesterol-dependent membrane regions that are reversibly regulated by ionotropic glutamate receptors activation.

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Autores principales:	Troels Rahbek-Clemmensen, Matthew D. Lycas, Simon Erlendsson, Jacob Eriksen, Mia Apuschkin, Frederik Vilhardt, Trine N. Jørgensen, Freja H. Hansen, Ulrik Gether
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94adb06557e442279abc6255c4796f9c
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spelling	oai:doaj.org-article:94adb06557e442279abc6255c4796f9c2021-12-02T14:42:07ZSuper-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains10.1038/s41467-017-00790-32041-1723https://doaj.org/article/94adb06557e442279abc6255c4796f9c2017-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00790-3https://doaj.org/toc/2041-1723The dopamine transporter (DAT) has a crucial role in the regulation of neurotransmission. Here, the authors use super-resolution imaging to show that DAT clusters into cholesterol-dependent membrane regions that are reversibly regulated by ionotropic glutamate receptors activation.Troels Rahbek-ClemmensenMatthew D. LycasSimon ErlendssonJacob EriksenMia ApuschkinFrederik VilhardtTrine N. JørgensenFreja H. HansenUlrik GetherNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Troels Rahbek-Clemmensen Matthew D. Lycas Simon Erlendsson Jacob Eriksen Mia Apuschkin Frederik Vilhardt Trine N. Jørgensen Freja H. Hansen Ulrik Gether Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
description	The dopamine transporter (DAT) has a crucial role in the regulation of neurotransmission. Here, the authors use super-resolution imaging to show that DAT clusters into cholesterol-dependent membrane regions that are reversibly regulated by ionotropic glutamate receptors activation.
format	article
author	Troels Rahbek-Clemmensen Matthew D. Lycas Simon Erlendsson Jacob Eriksen Mia Apuschkin Frederik Vilhardt Trine N. Jørgensen Freja H. Hansen Ulrik Gether
author_facet	Troels Rahbek-Clemmensen Matthew D. Lycas Simon Erlendsson Jacob Eriksen Mia Apuschkin Frederik Vilhardt Trine N. Jørgensen Freja H. Hansen Ulrik Gether
author_sort	Troels Rahbek-Clemmensen
title	Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
title_short	Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
title_full	Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
title_fullStr	Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
title_full_unstemmed	Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
title_sort	super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94adb06557e442279abc6255c4796f9c
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Super-resolution microscopy reveals functional organization of dopamine transporters into cholesterol and neuronal activity-dependent nanodomains

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