Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

“Variation in the noncoding regulatory sequences in the genome plays important roles in human disease and evolution. Here, the authors use F1 mouse hybrids to shed light on the regulatory mechanisms mediating transcription factor binding, chromatin state and gene expression in mammalian cells.”

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Autores principales:	Emily S. Wong, Bianca M. Schmitt, Anastasiya Kazachenka, David Thybert, Aisling Redmond, Frances Connor, Tim F. Rayner, Christine Feig, Anne C. Ferguson-Smith, John C. Marioni, Duncan T. Odom, Paul Flicek
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94b3385fc76e4d38a4ca428bdd92d65a
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spelling	oai:doaj.org-article:94b3385fc76e4d38a4ca428bdd92d65a2021-12-02T17:01:24ZInterplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution10.1038/s41467-017-01037-x2041-1723https://doaj.org/article/94b3385fc76e4d38a4ca428bdd92d65a2017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01037-xhttps://doaj.org/toc/2041-1723“Variation in the noncoding regulatory sequences in the genome plays important roles in human disease and evolution. Here, the authors use F1 mouse hybrids to shed light on the regulatory mechanisms mediating transcription factor binding, chromatin state and gene expression in mammalian cells.”Emily S. WongBianca M. SchmittAnastasiya KazachenkaDavid ThybertAisling RedmondFrances ConnorTim F. RaynerChristine FeigAnne C. Ferguson-SmithJohn C. MarioniDuncan T. OdomPaul FlicekNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emily S. Wong Bianca M. Schmitt Anastasiya Kazachenka David Thybert Aisling Redmond Frances Connor Tim F. Rayner Christine Feig Anne C. Ferguson-Smith John C. Marioni Duncan T. Odom Paul Flicek Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
description	“Variation in the noncoding regulatory sequences in the genome plays important roles in human disease and evolution. Here, the authors use F1 mouse hybrids to shed light on the regulatory mechanisms mediating transcription factor binding, chromatin state and gene expression in mammalian cells.”
format	article
author	Emily S. Wong Bianca M. Schmitt Anastasiya Kazachenka David Thybert Aisling Redmond Frances Connor Tim F. Rayner Christine Feig Anne C. Ferguson-Smith John C. Marioni Duncan T. Odom Paul Flicek
author_facet	Emily S. Wong Bianca M. Schmitt Anastasiya Kazachenka David Thybert Aisling Redmond Frances Connor Tim F. Rayner Christine Feig Anne C. Ferguson-Smith John C. Marioni Duncan T. Odom Paul Flicek
author_sort	Emily S. Wong
title	Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
title_short	Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
title_full	Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
title_fullStr	Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
title_full_unstemmed	Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
title_sort	interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94b3385fc76e4d38a4ca428bdd92d65a
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Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution

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