A draft map of the mouse pluripotent stem cell spatial proteome

The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution—and apply it to mouse pluripotent stem cells....

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Autores principales: Andy Christoforou, Claire M. Mulvey, Lisa M. Breckels, Aikaterini Geladaki, Tracey Hurrell, Penelope C. Hayward, Thomas Naake, Laurent Gatto, Rosa Viner, Alfonso Martinez Arias, Kathryn S. Lilley
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/94b699fb21c4417090182a6c8cb87d48
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Sumario:The spatial location of proteins within a cell is a key element of protein function. Here the authors describe hyperLOPIT—a proteomics workflow that allows the simultaneous assignment of thousands of proteins to subcellular niches with high resolution—and apply it to mouse pluripotent stem cells.