Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo

Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant...

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Autores principales:	Simon D. Fisher, Paul B. Robertson, Melony J. Black, Peter Redgrave, Mark A. Sagar, Wickliffe C. Abraham, John N.J. Reynolds
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94ba55734bfc4318a5c02d00eab6d896
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spelling	oai:doaj.org-article:94ba55734bfc4318a5c02d00eab6d8962021-12-02T14:42:25ZReinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo10.1038/s41467-017-00394-x2041-1723https://doaj.org/article/94ba55734bfc4318a5c02d00eab6d8962017-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-00394-xhttps://doaj.org/toc/2041-1723Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant reinforcement signals, mediated by dopamine and adenosine signaling.Simon D. FisherPaul B. RobertsonMelony J. BlackPeter RedgraveMark A. SagarWickliffe C. AbrahamJohn N.J. ReynoldsNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simon D. Fisher Paul B. Robertson Melony J. Black Peter Redgrave Mark A. Sagar Wickliffe C. Abraham John N.J. Reynolds Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
description	Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant reinforcement signals, mediated by dopamine and adenosine signaling.
format	article
author	Simon D. Fisher Paul B. Robertson Melony J. Black Peter Redgrave Mark A. Sagar Wickliffe C. Abraham John N.J. Reynolds
author_facet	Simon D. Fisher Paul B. Robertson Melony J. Black Peter Redgrave Mark A. Sagar Wickliffe C. Abraham John N.J. Reynolds
author_sort	Simon D. Fisher
title	Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
title_short	Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
title_full	Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
title_fullStr	Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
title_full_unstemmed	Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
title_sort	reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94ba55734bfc4318a5c02d00eab6d896
work_keys_str_mv	AT simondfisher reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo AT paulbrobertson reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo AT melonyjblack reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo AT peterredgrave reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo AT markasagar reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo AT wickliffecabraham reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo AT johnnjreynolds reinforcementdeterminesthetimingdependenceofcorticostriatalsynapticplasticityinvivo
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Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo

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