Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo

Reinforcement determines the timing dependence of corticostriatal synaptic plasticity in vivo

Spike timing dependent plasticity (STDP) has been studied extensively in slices but whether such pairings can induce plasticity in vivo is not known. Here the authors report an experimental paradigm that achieves bidirectional corticostriatal STDP in vivo through modulation by behaviourally relevant...

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Autores principales: Simon D. Fisher, Paul B. Robertson, Melony J. Black, Peter Redgrave, Mark A. Sagar, Wickliffe C. Abraham, John N.J. Reynolds
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
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Acceso en línea:https://doaj.org/article/94ba55734bfc4318a5c02d00eab6d896
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