A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

Identifying causal variants and genes is an essential step in interpreting GWAS loci. Here, the authors investigate a kidney disease GWAS locus with functional genomics data, CRISPR editing and mouse experiments to identify DPEP1 and CHMP1A as putative kidney disease genes via ferroptosis.

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Autores principales:	Yuting Guan, Xiujie Liang, Ziyuan Ma, Hailong Hu, Hongbo Liu, Zhen Miao, Andreas Linkermann, Jacklyn N. Hellwege, Benjamin F. Voight, Katalin Susztak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/94c00b491872474289c332bf354c853a
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spelling	oai:doaj.org-article:94c00b491872474289c332bf354c853a2021-12-02T16:34:55ZA single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis10.1038/s41467-021-25377-x2041-1723https://doaj.org/article/94c00b491872474289c332bf354c853a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25377-xhttps://doaj.org/toc/2041-1723Identifying causal variants and genes is an essential step in interpreting GWAS loci. Here, the authors investigate a kidney disease GWAS locus with functional genomics data, CRISPR editing and mouse experiments to identify DPEP1 and CHMP1A as putative kidney disease genes via ferroptosis.Yuting GuanXiujie LiangZiyuan MaHailong HuHongbo LiuZhen MiaoAndreas LinkermannJacklyn N. HellwegeBenjamin F. VoightKatalin SusztakNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yuting Guan Xiujie Liang Ziyuan Ma Hailong Hu Hongbo Liu Zhen Miao Andreas Linkermann Jacklyn N. Hellwege Benjamin F. Voight Katalin Susztak A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
description	Identifying causal variants and genes is an essential step in interpreting GWAS loci. Here, the authors investigate a kidney disease GWAS locus with functional genomics data, CRISPR editing and mouse experiments to identify DPEP1 and CHMP1A as putative kidney disease genes via ferroptosis.
format	article
author	Yuting Guan Xiujie Liang Ziyuan Ma Hailong Hu Hongbo Liu Zhen Miao Andreas Linkermann Jacklyn N. Hellwege Benjamin F. Voight Katalin Susztak
author_facet	Yuting Guan Xiujie Liang Ziyuan Ma Hailong Hu Hongbo Liu Zhen Miao Andreas Linkermann Jacklyn N. Hellwege Benjamin F. Voight Katalin Susztak
author_sort	Yuting Guan
title	A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
title_short	A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
title_full	A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
title_fullStr	A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
title_full_unstemmed	A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis
title_sort	single genetic locus controls both expression of dpep1/chmp1a and kidney disease development via ferroptosis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/94c00b491872474289c332bf354c853a
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A single genetic locus controls both expression of DPEP1/CHMP1A and kidney disease development via ferroptosis

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