Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy

Bin Zhao,1,2 Hu Liu,3 Huanhuan Li,3 Xiuli Shang1 1Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; 2Department of Neurology, Shenyang Fifth People Hospital, Shenyang 110023, China; 3Department of Radiology, The First Affiliated Hospital of...

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Autores principales:	Zhao B, Liu H, Li H, Shang X
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Multiple system atrophy depression functional magnetic resonance imaging functional connectivity amygdala Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/94c16c8294404e77b491556cddc22938
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spelling	oai:doaj.org-article:94c16c8294404e77b491556cddc229382021-12-02T01:41:48ZAbnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy1178-2021https://doaj.org/article/94c16c8294404e77b491556cddc229382018-11-01T00:00:00Zhttps://www.dovepress.com/abnormal-functional-connectivity-of-the-amygdala-is-associated-with-de-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Bin Zhao,1,2 Hu Liu,3 Huanhuan Li,3 Xiuli Shang1 1Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; 2Department of Neurology, Shenyang Fifth People Hospital, Shenyang 110023, China; 3Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China Purpose: Depressive symptoms are frequent nonmotor symptoms that occur in multiple system atrophy (MSA) patients. However, possible changes that can present in the amygdala (AMY) functional connectivity (FC) of the brain in MSA patients with depressive symptoms (DMSA patients) remain largely unknown. Materials and methods: Resting-state functional magnetic resonance imaging scans were obtained from 29 DMSA patients, 28 MSA patients without depression symptoms (NDMSA patients), and 34 healthy controls (HCs). FC was analyzed by defining the bilateral AMY as the seed region. Correlation analysis was performed between the FC and clinical scores. Results: When compared with NDMSA patients, DMSA patients showed increased bilateral AMY FC in the left middle frontal gyrus (MFG) and decreased right AMY FC in the left middle occipital gyrus. Moreover, the AMY FC values in the left middle frontal cortex were positively correlated with the Hamilton Depression Rating Scale-17 item scores. Furthermore, relative to the HCs, DMSA patients presented decreased bilateral AMY FC values in the visuospatial cortex, sensorimotor networks, and limbic areas. Conclusion: Depressive symptoms are associated with AMY–MFG FC anomalies in MSA patients. We propose that the middle frontal cortex may play an important role in the neuropathophysiology of depression in MSA patients. Keywords: multiple system atrophy, depression, functional magnetic resonance imaging, functional connectivity, amygdalaZhao BLiu HLi HShang XDove Medical PressarticleMultiple system atrophydepressionfunctional magnetic resonance imagingfunctional connectivityamygdalaNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3133-3142 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Multiple system atrophy depression functional magnetic resonance imaging functional connectivity amygdala Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Multiple system atrophy depression functional magnetic resonance imaging functional connectivity amygdala Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhao B Liu H Li H Shang X Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
description	Bin Zhao,1,2 Hu Liu,3 Huanhuan Li,3 Xiuli Shang1 1Department of Neurology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China; 2Department of Neurology, Shenyang Fifth People Hospital, Shenyang 110023, China; 3Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang 110001, China Purpose: Depressive symptoms are frequent nonmotor symptoms that occur in multiple system atrophy (MSA) patients. However, possible changes that can present in the amygdala (AMY) functional connectivity (FC) of the brain in MSA patients with depressive symptoms (DMSA patients) remain largely unknown. Materials and methods: Resting-state functional magnetic resonance imaging scans were obtained from 29 DMSA patients, 28 MSA patients without depression symptoms (NDMSA patients), and 34 healthy controls (HCs). FC was analyzed by defining the bilateral AMY as the seed region. Correlation analysis was performed between the FC and clinical scores. Results: When compared with NDMSA patients, DMSA patients showed increased bilateral AMY FC in the left middle frontal gyrus (MFG) and decreased right AMY FC in the left middle occipital gyrus. Moreover, the AMY FC values in the left middle frontal cortex were positively correlated with the Hamilton Depression Rating Scale-17 item scores. Furthermore, relative to the HCs, DMSA patients presented decreased bilateral AMY FC values in the visuospatial cortex, sensorimotor networks, and limbic areas. Conclusion: Depressive symptoms are associated with AMY–MFG FC anomalies in MSA patients. We propose that the middle frontal cortex may play an important role in the neuropathophysiology of depression in MSA patients. Keywords: multiple system atrophy, depression, functional magnetic resonance imaging, functional connectivity, amygdala
format	article
author	Zhao B Liu H Li H Shang X
author_facet	Zhao B Liu H Li H Shang X
author_sort	Zhao B
title	Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
title_short	Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
title_full	Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
title_fullStr	Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
title_full_unstemmed	Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
title_sort	abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/94c16c8294404e77b491556cddc22938
work_keys_str_mv	AT zhaob abnormalfunctionalconnectivityoftheamygdalaisassociatedwithdepressivesymptomsinpatientswithmultiplesystematrophy AT liuh abnormalfunctionalconnectivityoftheamygdalaisassociatedwithdepressivesymptomsinpatientswithmultiplesystematrophy AT lih abnormalfunctionalconnectivityoftheamygdalaisassociatedwithdepressivesymptomsinpatientswithmultiplesystematrophy AT shangx abnormalfunctionalconnectivityoftheamygdalaisassociatedwithdepressivesymptomsinpatientswithmultiplesystematrophy
_version_	1718402908659122176

Abnormal functional connectivity of the amygdala is associated with depressive symptoms in patients with multiple system atrophy

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