Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study

The present study investigated the effect of Lepidium sativum L. on Memory and on Acetylcholinesterase (AChE) activity in different brain structures among cadmium-exposed rats. Animals were divided into three groups: Control group (T): received a distilled water orally, Cadmium group (Cd): received...

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Autores principales:	Ed-Day Soumia, Boulbaroud Samira, Didou Latifa, Elgui Radia, Ahami Ahmed, Azzaoui Fatima-Zahra
Formato:	article
Lenguaje:	EN FR
Publicado:	EDP Sciences 2021
Materias:	Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/94c53886566d4eb1ab63ad924f60c4c1
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spelling	oai:doaj.org-article:94c53886566d4eb1ab63ad924f60c4c12021-11-12T11:44:08ZNeuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study2267-124210.1051/e3sconf/202131901015https://doaj.org/article/94c53886566d4eb1ab63ad924f60c4c12021-01-01T00:00:00Zhttps://www.e3s-conferences.org/articles/e3sconf/pdf/2021/95/e3sconf_vigisan_01015.pdfhttps://doaj.org/toc/2267-1242The present study investigated the effect of Lepidium sativum L. on Memory and on Acetylcholinesterase (AChE) activity in different brain structures among cadmium-exposed rats. Animals were divided into three groups: Control group (T): received a distilled water orally, Cadmium group (Cd): received oral administration dose of Cadmium Chloride (CdCl2) at 10 mg/kg, Protective group (Cd/LS): received CdCl2 (10mg/kg) and the aqueous extract of Lepidium sativum L. (20mg/kg) orally. The Novel Object Recognition Memory Test is used to evaluate the short and long term memory. The measure of AchE activity is realized by Ellman’s method. The results showed that subchronic Cadmium Chloride intoxication at a dose of 10 mg/kg caused a neurobehavioral impairments including: A significant decrease in the index of recognition of short-term (p<0.01) and long-term memory (p <0.05) compared to the control group. In addition, this index increase in the group (Cd/LS) compared to the group intoxicated by CdCl2. A highly significant increase in the enzymatic activity of acetylcholinesterase in hippocampus, cerebellum, and cortex (p<0.001) is registered. These results indicate that the aqueous extract of Lepidium sativum L. may modulate the toxic effect induced by cadmium and consequently improve cognition.Ed-Day SoumiaBoulbaroud SamiraDidou LatifaElgui RadiaAhami AhmedAzzaoui Fatima-ZahraEDP SciencesarticleEnvironmental sciencesGE1-350ENFRE3S Web of Conferences, Vol 319, p 01015 (2021)
institution	DOAJ
collection	DOAJ
language	EN FR
topic	Environmental sciences GE1-350
spellingShingle	Environmental sciences GE1-350 Ed-Day Soumia Boulbaroud Samira Didou Latifa Elgui Radia Ahami Ahmed Azzaoui Fatima-Zahra Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
description	The present study investigated the effect of Lepidium sativum L. on Memory and on Acetylcholinesterase (AChE) activity in different brain structures among cadmium-exposed rats. Animals were divided into three groups: Control group (T): received a distilled water orally, Cadmium group (Cd): received oral administration dose of Cadmium Chloride (CdCl2) at 10 mg/kg, Protective group (Cd/LS): received CdCl2 (10mg/kg) and the aqueous extract of Lepidium sativum L. (20mg/kg) orally. The Novel Object Recognition Memory Test is used to evaluate the short and long term memory. The measure of AchE activity is realized by Ellman’s method. The results showed that subchronic Cadmium Chloride intoxication at a dose of 10 mg/kg caused a neurobehavioral impairments including: A significant decrease in the index of recognition of short-term (p<0.01) and long-term memory (p <0.05) compared to the control group. In addition, this index increase in the group (Cd/LS) compared to the group intoxicated by CdCl2. A highly significant increase in the enzymatic activity of acetylcholinesterase in hippocampus, cerebellum, and cortex (p<0.001) is registered. These results indicate that the aqueous extract of Lepidium sativum L. may modulate the toxic effect induced by cadmium and consequently improve cognition.
format	article
author	Ed-Day Soumia Boulbaroud Samira Didou Latifa Elgui Radia Ahami Ahmed Azzaoui Fatima-Zahra
author_facet	Ed-Day Soumia Boulbaroud Samira Didou Latifa Elgui Radia Ahami Ahmed Azzaoui Fatima-Zahra
author_sort	Ed-Day Soumia
title	Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
title_short	Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
title_full	Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
title_fullStr	Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
title_full_unstemmed	Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study
title_sort	neuroprotective effects of lepidium sativum l. on memory impairments in wistar rat: behavioral and neurochemical study
publisher	EDP Sciences
publishDate	2021
url	https://doaj.org/article/94c53886566d4eb1ab63ad924f60c4c1
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Neuroprotective effects of Lepidium sativum L. on memory impairments in Wistar rat: Behavioral and neurochemical study

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