Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment
Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation...
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Nature Portfolio
2018
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oai:doaj.org-article:94c549222fd542cf9308dbd596a1cb4c2021-12-02T17:32:18ZCis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment10.1038/s41467-018-07506-12041-1723https://doaj.org/article/94c549222fd542cf9308dbd596a1cb4c2018-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-07506-1https://doaj.org/toc/2041-1723Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation specifically implicated in this interaction.Gurpanna SagguKoshu OkuboYunfeng ChenRavi VattepuNaotake TsuboiFlorencia RosettiXavier CullereNathaniel WashburnSuhail TahirAaron M. RosadoSteven M. HollandRobert M. AnthonyMehmet SenCheng ZhuTanya N. MayadasNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Gurpanna Saggu Koshu Okubo Yunfeng Chen Ravi Vattepu Naotake Tsuboi Florencia Rosetti Xavier Cullere Nathaniel Washburn Suhail Tahir Aaron M. Rosado Steven M. Holland Robert M. Anthony Mehmet Sen Cheng Zhu Tanya N. Mayadas Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment |
| description |
Deposited immune complexes (IC) promote neutrophil recruitment, but the fine tuning of this process is still unclear. Here the authors show that the cis interaction of the IC receptor, FcγRIIA and CD18 integrin, Mac-1, on the neutrophil surface modulates neutrophil adhesion, with FcγRIIA sialylation specifically implicated in this interaction. |
| format |
article |
| author |
Gurpanna Saggu Koshu Okubo Yunfeng Chen Ravi Vattepu Naotake Tsuboi Florencia Rosetti Xavier Cullere Nathaniel Washburn Suhail Tahir Aaron M. Rosado Steven M. Holland Robert M. Anthony Mehmet Sen Cheng Zhu Tanya N. Mayadas |
| author_facet |
Gurpanna Saggu Koshu Okubo Yunfeng Chen Ravi Vattepu Naotake Tsuboi Florencia Rosetti Xavier Cullere Nathaniel Washburn Suhail Tahir Aaron M. Rosado Steven M. Holland Robert M. Anthony Mehmet Sen Cheng Zhu Tanya N. Mayadas |
| author_sort |
Gurpanna Saggu |
| title |
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment |
| title_short |
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment |
| title_full |
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment |
| title_fullStr |
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment |
| title_full_unstemmed |
Cis interaction between sialylated FcγRIIA and the αI-domain of Mac-1 limits antibody-mediated neutrophil recruitment |
| title_sort |
cis interaction between sialylated fcγriia and the αi-domain of mac-1 limits antibody-mediated neutrophil recruitment |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/94c549222fd542cf9308dbd596a1cb4c |
| work_keys_str_mv |
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| _version_ |
1718380321493221376 |