Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.

<h4>Background</h4>Household transmission of influenza can affect the daily lives of patients and their families and be a trigger for community transmission, thus it is necessary to take precautions to prevent household transmission. We aimed to determine the risks of household transmiss...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Nobuo Hirotsu, Koji Wada, Hitoshi Oshitani
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94c5bedeb84b4ec6b3e80e1ee43e89b3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:94c5bedeb84b4ec6b3e80e1ee43e89b3
record_format	dspace
spelling	oai:doaj.org-article:94c5bedeb84b4ec6b3e80e1ee43e89b32021-11-18T07:27:59ZRisk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.1932-620310.1371/journal.pone.0031519https://doaj.org/article/94c5bedeb84b4ec6b3e80e1ee43e89b32012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22359599/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Household transmission of influenza can affect the daily lives of patients and their families and be a trigger for community transmission, thus it is necessary to take precautions to prevent household transmission. We aimed to determine the risks of household transmission of pandemic (H1N1) 2009 influenza virus from an index patient who visited a primary clinic and was treated with antiviral drugs.<h4>Methods</h4>We followed up all the patients who were diagnosed with influenza A by rapid diagnostic test with a questionnaire or interview from July 2009 to April 2010. Secondary cases were defined as patients visiting the clinic or other clinics and being positive for influenza A by rapid diagnostic test within 7 days of onset of an index patient. Logistic regression analysis was used to explore the association between household transmission and the studied variables.<h4>Results</h4>We recruited 591 index patients and 1629 household contacts. The crude secondary attack rate was 7.3% [95% confidence interval (CI): 6.1-8.7]. Age of index patients (0-6 years old: odds ratio 2.56; 95% CI: 1.31-4.01; 7-12 years old: 2.44, 1.31-3.72; 30-39 years old 3.88; 2.09-5.21; 40 years old or more 2.76; 1.17-4.53) and number of household members with five or more (3.09, 2.11-4.07), medication started ≥48 hours from the onset of fever (2.38, 1.17-3.87) were significantly associated with household transmission.<h4>Conclusions</h4>Household transmission was associated with index patients aged ≤12 years old and adults ≥30 years with children, with more than five persons in the household, and medication initiated ≥48 hours from the onset of fever among the population, in which, antiviral treatment was given to all patients. We need to warn patients at high risk of household transmission to take additional precautions.Nobuo HirotsuKoji WadaHitoshi OshitaniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 2, p e31519 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nobuo Hirotsu Koji Wada Hitoshi Oshitani Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.
description	<h4>Background</h4>Household transmission of influenza can affect the daily lives of patients and their families and be a trigger for community transmission, thus it is necessary to take precautions to prevent household transmission. We aimed to determine the risks of household transmission of pandemic (H1N1) 2009 influenza virus from an index patient who visited a primary clinic and was treated with antiviral drugs.<h4>Methods</h4>We followed up all the patients who were diagnosed with influenza A by rapid diagnostic test with a questionnaire or interview from July 2009 to April 2010. Secondary cases were defined as patients visiting the clinic or other clinics and being positive for influenza A by rapid diagnostic test within 7 days of onset of an index patient. Logistic regression analysis was used to explore the association between household transmission and the studied variables.<h4>Results</h4>We recruited 591 index patients and 1629 household contacts. The crude secondary attack rate was 7.3% [95% confidence interval (CI): 6.1-8.7]. Age of index patients (0-6 years old: odds ratio 2.56; 95% CI: 1.31-4.01; 7-12 years old: 2.44, 1.31-3.72; 30-39 years old 3.88; 2.09-5.21; 40 years old or more 2.76; 1.17-4.53) and number of household members with five or more (3.09, 2.11-4.07), medication started ≥48 hours from the onset of fever (2.38, 1.17-3.87) were significantly associated with household transmission.<h4>Conclusions</h4>Household transmission was associated with index patients aged ≤12 years old and adults ≥30 years with children, with more than five persons in the household, and medication initiated ≥48 hours from the onset of fever among the population, in which, antiviral treatment was given to all patients. We need to warn patients at high risk of household transmission to take additional precautions.
format	article
author	Nobuo Hirotsu Koji Wada Hitoshi Oshitani
author_facet	Nobuo Hirotsu Koji Wada Hitoshi Oshitani
author_sort	Nobuo Hirotsu
title	Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.
title_short	Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.
title_full	Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.
title_fullStr	Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.
title_full_unstemmed	Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.
title_sort	risk factors of household transmission of pandemic (h1n1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in japan.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/94c5bedeb84b4ec6b3e80e1ee43e89b3
work_keys_str_mv	AT nobuohirotsu riskfactorsofhouseholdtransmissionofpandemich1n12009amongpatientstreatedwithantiviralsaprospectivestudyataprimaryclinicinjapan AT kojiwada riskfactorsofhouseholdtransmissionofpandemich1n12009amongpatientstreatedwithantiviralsaprospectivestudyataprimaryclinicinjapan AT hitoshioshitani riskfactorsofhouseholdtransmissionofpandemich1n12009amongpatientstreatedwithantiviralsaprospectivestudyataprimaryclinicinjapan
_version_	1718423425465188352

Risk factors of household transmission of pandemic (H1N1) 2009 among patients treated with antivirals: a prospective study at a primary clinic in Japan.

Ejemplares similares