Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo

Neutrophils play an important role in antimicrobial host defence but can also contribute to non-infectious inflammatory processes. Here the authors show that adaptor protein CARD9 expressed in neutrophils is involved in the development of sterile auto-antibody-mediated inflammatory reactions.

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Autores principales: Tamás Németh, Krisztina Futosi, Cassian Sitaru, Jürgen Ruland, Attila Mócsai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/94c8db3bf3c744779c35e4047064e4a3
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spelling oai:doaj.org-article:94c8db3bf3c744779c35e4047064e4a32021-12-02T16:56:47ZNeutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo10.1038/ncomms110042041-1723https://doaj.org/article/94c8db3bf3c744779c35e4047064e4a32016-04-01T00:00:00Zhttps://doi.org/10.1038/ncomms11004https://doaj.org/toc/2041-1723Neutrophils play an important role in antimicrobial host defence but can also contribute to non-infectious inflammatory processes. Here the authors show that adaptor protein CARD9 expressed in neutrophils is involved in the development of sterile auto-antibody-mediated inflammatory reactions.Tamás NémethKrisztina FutosiCassian SitaruJürgen RulandAttila MócsaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Tamás Németh
Krisztina Futosi
Cassian Sitaru
Jürgen Ruland
Attila Mócsai
Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
description Neutrophils play an important role in antimicrobial host defence but can also contribute to non-infectious inflammatory processes. Here the authors show that adaptor protein CARD9 expressed in neutrophils is involved in the development of sterile auto-antibody-mediated inflammatory reactions.
format article
author Tamás Németh
Krisztina Futosi
Cassian Sitaru
Jürgen Ruland
Attila Mócsai
author_facet Tamás Németh
Krisztina Futosi
Cassian Sitaru
Jürgen Ruland
Attila Mócsai
author_sort Tamás Németh
title Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
title_short Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
title_full Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
title_fullStr Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
title_full_unstemmed Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
title_sort neutrophil-specific deletion of the card9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/94c8db3bf3c744779c35e4047064e4a3
work_keys_str_mv AT tamasnemeth neutrophilspecificdeletionofthecard9geneexpressionregulatorsuppressesautoantibodyinducedinflammationinvivo
AT krisztinafutosi neutrophilspecificdeletionofthecard9geneexpressionregulatorsuppressesautoantibodyinducedinflammationinvivo
AT cassiansitaru neutrophilspecificdeletionofthecard9geneexpressionregulatorsuppressesautoantibodyinducedinflammationinvivo
AT jurgenruland neutrophilspecificdeletionofthecard9geneexpressionregulatorsuppressesautoantibodyinducedinflammationinvivo
AT attilamocsai neutrophilspecificdeletionofthecard9geneexpressionregulatorsuppressesautoantibodyinducedinflammationinvivo
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