Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia

Few reports are available on children with pre-extensively drug-resistant tuberculosis (pre-XDR-TB), which is defined as Mycobacterium tuberculosis resistant to both isoniazid and rifampicin plus resistance to either a fluoroquinolone or a second-line injectable drug. Pre-XDR-TB treatment for childr...

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Autores principales:	Heda Melinda Nataprawira, Indah Septiane, Sri Sudarwati, Diah Asri Wulandari
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Pre-extensively drug resistant tuberculosis Children Case report Diseases of the respiratory system RC705-779
Acceso en línea:	https://doaj.org/article/94cdfe0590824cdf92179d9097002509
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spelling	oai:doaj.org-article:94cdfe0590824cdf92179d90970025092021-11-14T04:32:38ZTwo cases of pre-extensively drug resistant tuberculosis in children in Indonesia2213-007110.1016/j.rmcr.2021.101544https://doaj.org/article/94cdfe0590824cdf92179d90970025092021-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2213007121002069https://doaj.org/toc/2213-0071Few reports are available on children with pre-extensively drug-resistant tuberculosis (pre-XDR-TB), which is defined as Mycobacterium tuberculosis resistant to both isoniazid and rifampicin plus resistance to either a fluoroquinolone or a second-line injectable drug. Pre-XDR-TB treatment for children usually has been individualized based on drug susceptibility test (DST) results, but treatment remains challenging due to the lack of studies based on existing treatment guidelines in children and lack of availability of the new drugs. We report two cases of pre-XDR-TB in children who have responded well to individualized treatment regimens. Because toxic drugs are used for long duration, close monitoring of adverse drug reactions is important.Heda Melinda NataprawiraIndah SeptianeSri SudarwatiDiah Asri WulandariElsevierarticlePre-extensively drug resistant tuberculosisChildrenCase reportDiseases of the respiratory systemRC705-779ENRespiratory Medicine Case Reports, Vol 34, Iss , Pp 101544- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pre-extensively drug resistant tuberculosis Children Case report Diseases of the respiratory system RC705-779
spellingShingle	Pre-extensively drug resistant tuberculosis Children Case report Diseases of the respiratory system RC705-779 Heda Melinda Nataprawira Indah Septiane Sri Sudarwati Diah Asri Wulandari Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia
description	Few reports are available on children with pre-extensively drug-resistant tuberculosis (pre-XDR-TB), which is defined as Mycobacterium tuberculosis resistant to both isoniazid and rifampicin plus resistance to either a fluoroquinolone or a second-line injectable drug. Pre-XDR-TB treatment for children usually has been individualized based on drug susceptibility test (DST) results, but treatment remains challenging due to the lack of studies based on existing treatment guidelines in children and lack of availability of the new drugs. We report two cases of pre-XDR-TB in children who have responded well to individualized treatment regimens. Because toxic drugs are used for long duration, close monitoring of adverse drug reactions is important.
format	article
author	Heda Melinda Nataprawira Indah Septiane Sri Sudarwati Diah Asri Wulandari
author_facet	Heda Melinda Nataprawira Indah Septiane Sri Sudarwati Diah Asri Wulandari
author_sort	Heda Melinda Nataprawira
title	Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia
title_short	Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia
title_full	Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia
title_fullStr	Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia
title_full_unstemmed	Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia
title_sort	two cases of pre-extensively drug resistant tuberculosis in children in indonesia
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/94cdfe0590824cdf92179d9097002509
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Two cases of pre-extensively drug resistant tuberculosis in children in Indonesia

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