Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide

Saeid Koocheki1, Sayed Siavash Madaeni1, Parisa Niroomandi21Membrane Research Center, Chemical Engineering Department, Razi University, Kermanshah, Iran; 2Exir Pharmaceutical Co, Lorestan, Boroujerd, IranAbstract: We report an analysis of in vitro and in vivo drug release from an in situ formulation...

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Autores principales:	Koocheki S, Madaeni SS, Niroomandi P
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2011
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/94ce7bef376245538288223e4a67a2e5
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spelling	oai:doaj.org-article:94ce7bef376245538288223e4a67a2e52021-12-02T02:10:29ZApplication of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide1176-91141178-2013https://doaj.org/article/94ce7bef376245538288223e4a67a2e52011-04-01T00:00:00Zhttp://www.dovepress.com/application-of-hydroxyapatite-nanoparticles-in-development-of-an-enhan-a7153https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Saeid Koocheki1, Sayed Siavash Madaeni1, Parisa Niroomandi21Membrane Research Center, Chemical Engineering Department, Razi University, Kermanshah, Iran; 2Exir Pharmaceutical Co, Lorestan, Boroujerd, IranAbstract: We report an analysis of in vitro and in vivo drug release from an in situ formulation consisting of triamcinolone acetonide (TR) and poly(D,L-lactide-co-glycolide) (PLGA) and the additives glycofurol (GL) and hydroxyapatite nanoparticles (HA). We found that these additives enhanced drug release rate. We used the Taguchi method to predict optimum formulation variables to minimize the initial burst. This method decreased the burst rate from 8% to 1.3%. PLGA-HA acted as a strong buffer, thereby preventing tissue inflammation at the injection site caused by the acidic degradation products of PLGA. Characterization of the optimized formulation by a variety of techniques, including scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and Fourier transform near infrared spectroscopy, revealed that the crystalline structure of TR was converted to an amorphous form. Therefore, this hydrophobic agent can serve as an additive to modify drug release rates. Data generated by in vitro and in vivo experiments were in good agreement.Keywords: triamcinolone acetonide, glycofurol, hydroxyapatite nanoparticle, PLGA Koocheki SMadaeni SSNiroomandi PDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2011, Iss default, Pp 825-833 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Koocheki S Madaeni SS Niroomandi P Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
description	Saeid Koocheki1, Sayed Siavash Madaeni1, Parisa Niroomandi21Membrane Research Center, Chemical Engineering Department, Razi University, Kermanshah, Iran; 2Exir Pharmaceutical Co, Lorestan, Boroujerd, IranAbstract: We report an analysis of in vitro and in vivo drug release from an in situ formulation consisting of triamcinolone acetonide (TR) and poly(D,L-lactide-co-glycolide) (PLGA) and the additives glycofurol (GL) and hydroxyapatite nanoparticles (HA). We found that these additives enhanced drug release rate. We used the Taguchi method to predict optimum formulation variables to minimize the initial burst. This method decreased the burst rate from 8% to 1.3%. PLGA-HA acted as a strong buffer, thereby preventing tissue inflammation at the injection site caused by the acidic degradation products of PLGA. Characterization of the optimized formulation by a variety of techniques, including scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, and Fourier transform near infrared spectroscopy, revealed that the crystalline structure of TR was converted to an amorphous form. Therefore, this hydrophobic agent can serve as an additive to modify drug release rates. Data generated by in vitro and in vivo experiments were in good agreement.Keywords: triamcinolone acetonide, glycofurol, hydroxyapatite nanoparticle, PLGA
format	article
author	Koocheki S Madaeni SS Niroomandi P
author_facet	Koocheki S Madaeni SS Niroomandi P
author_sort	Koocheki S
title	Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
title_short	Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
title_full	Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
title_fullStr	Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
title_full_unstemmed	Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
title_sort	application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide
publisher	Dove Medical Press
publishDate	2011
url	https://doaj.org/article/94ce7bef376245538288223e4a67a2e5
work_keys_str_mv	AT koochekis applicationofhydroxyapatitenanoparticlesindevelopmentofanenhancedformulationfordeliveringsustainedreleaseoftriamcinoloneacetonide AT madaeniss applicationofhydroxyapatitenanoparticlesindevelopmentofanenhancedformulationfordeliveringsustainedreleaseoftriamcinoloneacetonide AT niroomandip applicationofhydroxyapatitenanoparticlesindevelopmentofanenhancedformulationfordeliveringsustainedreleaseoftriamcinoloneacetonide
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Application of hydroxyapatite nanoparticles in development of an enhanced formulation for delivering sustained release of triamcinolone acetonide

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