Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma

Abstract Because population-based risk estimates for metachronous contralateral UTUC are lacking. In this study, we aimed to evaluate the risk and survival of metachronous contralateral upper tract urothelial carcinoma (UTUC) on a large population-based level. A total of 23,075 patients were identif...

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Autores principales:	Kan Wu, Jiayu Liang, Yiping Lu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94cf472cb1bf4842bf5fa850c9763ef4
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spelling	oai:doaj.org-article:94cf472cb1bf4842bf5fa850c9763ef42021-12-02T18:37:07ZRisk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma10.1038/s41598-020-73699-52045-2322https://doaj.org/article/94cf472cb1bf4842bf5fa850c9763ef42020-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-73699-5https://doaj.org/toc/2045-2322Abstract Because population-based risk estimates for metachronous contralateral UTUC are lacking. In this study, we aimed to evaluate the risk and survival of metachronous contralateral upper tract urothelial carcinoma (UTUC) on a large population-based level. A total of 23,075 patients were identified from the Surveillance, Epidemiology, and End Results database (1973–2015), 144 (0.6%) patients developed metachronous contralateral UTUC (median of 32 months after diagnosis). The cumulative incidence at 10, 20, and 30 years of follow-up was 1.1%, 1.6%, and 2.6%, respectively. We applied Fine and Gray’s competing risk regression model to determine the risk factors of a new contralateral, metachronous UTUC. The competing risk regression model demonstrated that older age (hazard ratio [HR] 0.75; 95% CI 0.67–0.85) and larger tumor size (HR 0.61; 95% CI 0.39–0.97) were associated with a significantly decreased risk of metachronous contralateral UTUC. However, bladder cancer presence was an independent risk factor for the development of contralateral tumors (HR 2.42; 95% CI 1.73–3.37). In addition, we demonstrated developing contralateral UTUC was not associated with poor prognosis by using Kaplan–Meier and multivariable analysis. Our findings suggest that metachronous contralateral UTUC is comparatively rare, and has not impact on survival. Importantly, patients with younger age, small tumours, and the presence of bladder cancer were more likely to develop a contralateral tumor, which may provide a rationale for lifelong surveillance in high-risk patients.Kan WuJiayu LiangYiping LuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kan Wu Jiayu Liang Yiping Lu Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
description	Abstract Because population-based risk estimates for metachronous contralateral UTUC are lacking. In this study, we aimed to evaluate the risk and survival of metachronous contralateral upper tract urothelial carcinoma (UTUC) on a large population-based level. A total of 23,075 patients were identified from the Surveillance, Epidemiology, and End Results database (1973–2015), 144 (0.6%) patients developed metachronous contralateral UTUC (median of 32 months after diagnosis). The cumulative incidence at 10, 20, and 30 years of follow-up was 1.1%, 1.6%, and 2.6%, respectively. We applied Fine and Gray’s competing risk regression model to determine the risk factors of a new contralateral, metachronous UTUC. The competing risk regression model demonstrated that older age (hazard ratio [HR] 0.75; 95% CI 0.67–0.85) and larger tumor size (HR 0.61; 95% CI 0.39–0.97) were associated with a significantly decreased risk of metachronous contralateral UTUC. However, bladder cancer presence was an independent risk factor for the development of contralateral tumors (HR 2.42; 95% CI 1.73–3.37). In addition, we demonstrated developing contralateral UTUC was not associated with poor prognosis by using Kaplan–Meier and multivariable analysis. Our findings suggest that metachronous contralateral UTUC is comparatively rare, and has not impact on survival. Importantly, patients with younger age, small tumours, and the presence of bladder cancer were more likely to develop a contralateral tumor, which may provide a rationale for lifelong surveillance in high-risk patients.
format	article
author	Kan Wu Jiayu Liang Yiping Lu
author_facet	Kan Wu Jiayu Liang Yiping Lu
author_sort	Kan Wu
title	Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
title_short	Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
title_full	Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
title_fullStr	Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
title_full_unstemmed	Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
title_sort	risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/94cf472cb1bf4842bf5fa850c9763ef4
work_keys_str_mv	AT kanwu riskfactorsandsurvivaloutcomesofmetachronouscontralateraluppertracturothelialcarcinoma AT jiayuliang riskfactorsandsurvivaloutcomesofmetachronouscontralateraluppertracturothelialcarcinoma AT yipinglu riskfactorsandsurvivaloutcomesofmetachronouscontralateraluppertracturothelialcarcinoma
_version_	1718377813312012288

Risk factors and survival outcomes of metachronous contralateral upper tract urothelial carcinoma

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