Dual regulation of cytoplasmic and mitochondrial acetyl-CoA utilization for improved isoprene production in Saccharomyces cerevisiae

Microbial production of isoprene from renewable feedstock is a promising alternative to petroleum-based processes. Here, the authors show that isoprene production in the yeast Saccharomyces cerevisiaecan be improved by dual metabolic engineering of cytoplasmic and mitochondrial acetyl-CoA utilizatio...

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Autores principales: Xiaomei Lv, Fan Wang, Pingping Zhou, Lidan Ye, Wenping Xie, Haoming Xu, Hongwei Yu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/94d43cdd94ac45db910740a41def94e5
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Sumario:Microbial production of isoprene from renewable feedstock is a promising alternative to petroleum-based processes. Here, the authors show that isoprene production in the yeast Saccharomyces cerevisiaecan be improved by dual metabolic engineering of cytoplasmic and mitochondrial acetyl-CoA utilization.