Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda

Background: Research into aetiologies and prevention of the commonest cancers and implementation of primary and secondary prevention can reduce cancer risk and improve quality of life. Moreover, monitoring the prevalence of cancer risk factors in a specific population helps guide cancer prevention a...

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Autores principales:	Alfred Jatho, Binh Thang Tran, Jansen Marcos Cambia, Miisa Nanyingi, Noleb Mugume Mugisha
Formato:	article
Lenguaje:	EN
Publicado:	Ubiquity Press 2020
Materias:	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/94db289b42414e48989db537873fab29
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spelling	oai:doaj.org-article:94db289b42414e48989db537873fab292021-12-02T08:10:16ZCancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda2214-999610.5334/aogh.2873https://doaj.org/article/94db289b42414e48989db537873fab292020-07-01T00:00:00Zhttps://annalsofglobalhealth.org/articles/2873https://doaj.org/toc/2214-9996Background: Research into aetiologies and prevention of the commonest cancers and implementation of primary and secondary prevention can reduce cancer risk and improve quality of life. Moreover, monitoring the prevalence of cancer risk factors in a specific population helps guide cancer prevention and early detection efforts and national cancer control programming. Objective: This article aims to provide the scope and findings of cancer risk studies conducted in Uganda to guide researchers, health-care professionals, and policymakers. Methods: Between November 2019 to January 2020, we searched peer-reviewed published articles in Pubmed, EMBASE and Cochrane Library (Cochrane central register of controlled trials-CENTRAL). We followed the recommendation of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses – the PRISMA. The primary focus was to identify cancer risk and prevention studies conducted in Uganda and published in peer-reviewed journals from January 2000 and January 2020. We used key Boolean search terms with their associated database strings. Results: We identified 416 articles, screened 269 non-duplicate articles and obtained 77 full-text articles for review. Out of the 77 studies, we identified one (1%) randomized trial, two (2.5%) retrospective cohort studies and 14 (18%) case-control studies, 46 (60%) cross-sectional studies, five (6.4%) ecological studies, three panel studies (4%) and six (8%) qualitative studies. Cervical cancer was the most studied type of cancer in Uganda (23.4%, n = 18 studies), followed by lymphomas – both Hodgkin and Non-Hodgkin sub-types (20.7%), n = 16 studies) and breast cancer (15.6%, n = 12 studies). In lymphoma studies, Burkitt lymphoma was the most studied type of lymphoma (76%, n = 13 studies). The studies concentrated on specific cancer risk awareness, risk perceptions, attitudes, uptake of screening, uptake of human papillomavirus vaccination, the prevalence of some of the known cancer risk factors and obstacles to accessing screening services. Conclusion: The unmet need for comprehensive cancer risk and prevention studies is enormous in Uganda. Future studies need to comprehensively investigate the known and putative cancer risk factors and prioritize the application of the higher-hierarchy evidence-generating epidemiological studies to guide planning of the national cancer control program.Alfred JathoBinh Thang TranJansen Marcos CambiaMiisa NanyingiNoleb Mugume MugishaUbiquity PressarticleInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENAnnals of Global Health, Vol 86, Iss 1 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270
spellingShingle	Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Alfred Jatho Binh Thang Tran Jansen Marcos Cambia Miisa Nanyingi Noleb Mugume Mugisha Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda
description	Background: Research into aetiologies and prevention of the commonest cancers and implementation of primary and secondary prevention can reduce cancer risk and improve quality of life. Moreover, monitoring the prevalence of cancer risk factors in a specific population helps guide cancer prevention and early detection efforts and national cancer control programming. Objective: This article aims to provide the scope and findings of cancer risk studies conducted in Uganda to guide researchers, health-care professionals, and policymakers. Methods: Between November 2019 to January 2020, we searched peer-reviewed published articles in Pubmed, EMBASE and Cochrane Library (Cochrane central register of controlled trials-CENTRAL). We followed the recommendation of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses – the PRISMA. The primary focus was to identify cancer risk and prevention studies conducted in Uganda and published in peer-reviewed journals from January 2000 and January 2020. We used key Boolean search terms with their associated database strings. Results: We identified 416 articles, screened 269 non-duplicate articles and obtained 77 full-text articles for review. Out of the 77 studies, we identified one (1%) randomized trial, two (2.5%) retrospective cohort studies and 14 (18%) case-control studies, 46 (60%) cross-sectional studies, five (6.4%) ecological studies, three panel studies (4%) and six (8%) qualitative studies. Cervical cancer was the most studied type of cancer in Uganda (23.4%, n = 18 studies), followed by lymphomas – both Hodgkin and Non-Hodgkin sub-types (20.7%), n = 16 studies) and breast cancer (15.6%, n = 12 studies). In lymphoma studies, Burkitt lymphoma was the most studied type of lymphoma (76%, n = 13 studies). The studies concentrated on specific cancer risk awareness, risk perceptions, attitudes, uptake of screening, uptake of human papillomavirus vaccination, the prevalence of some of the known cancer risk factors and obstacles to accessing screening services. Conclusion: The unmet need for comprehensive cancer risk and prevention studies is enormous in Uganda. Future studies need to comprehensively investigate the known and putative cancer risk factors and prioritize the application of the higher-hierarchy evidence-generating epidemiological studies to guide planning of the national cancer control program.
format	article
author	Alfred Jatho Binh Thang Tran Jansen Marcos Cambia Miisa Nanyingi Noleb Mugume Mugisha
author_facet	Alfred Jatho Binh Thang Tran Jansen Marcos Cambia Miisa Nanyingi Noleb Mugume Mugisha
author_sort	Alfred Jatho
title	Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda
title_short	Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda
title_full	Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda
title_fullStr	Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda
title_full_unstemmed	Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda
title_sort	cancer risk studies and priority areas for cancer risk appraisal in uganda
publisher	Ubiquity Press
publishDate	2020
url	https://doaj.org/article/94db289b42414e48989db537873fab29
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Cancer Risk Studies and Priority Areas for Cancer Risk Appraisal in Uganda

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