The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up

The first case of COVID-19 in Nigeria was recorded on February 27, 2020, being an imported case by an Italian expatriate, to the country. Since then, there has been steady increase in the number of cases. However, the number of cases in Nigeria is low in comparison to cases reported by other countri...

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Autores principales:	Olufemi Samuel Amoo, Funmi Adewara, Bosun Tijani, Tochukwu Ifeanyi Onuigbo, Amaka Stephanie Ikemefuna, Joy Isioma Oraegbu, Tazeen Rizvi, Azuka Okwuraiwe, Chika Onwuamah, Joseph Shaibu, Ayorinde James, Greg Ohihoin, Fehintola Ige, Dorcas Kareithi, Agatha David, Steven Karera, Hammed Agboola, Anthony Adeniyi, Josephine Obi, Dominic Achanya, Ebenezer Odewale, Osaga Oforomeh, Gideon Liboro, Olayemi Nwogbe, Oliver Ezechi, Richard Adegbola, Rosemary Audu, Babatunde Salako
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94dedcc3178f4ec68e8506279f0a52f4
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spelling	oai:doaj.org-article:94dedcc3178f4ec68e8506279f0a52f42021-11-11T07:14:41ZThe use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up1932-6203https://doaj.org/article/94dedcc3178f4ec68e8506279f0a52f42021-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC8568151/?tool=EBIhttps://doaj.org/toc/1932-6203The first case of COVID-19 in Nigeria was recorded on February 27, 2020, being an imported case by an Italian expatriate, to the country. Since then, there has been steady increase in the number of cases. However, the number of cases in Nigeria is low in comparison to cases reported by other countries with similar large populations, despite the poor health system prevailing in the country. This has been mainly attributed to the low testing capacity in Nigeria among other factors. Therefore, there is a need for innovative ways to increase the number of persons testing for COVID-19. The aim of the study was to pilot a nasopharyngeal swab self-sample collection model that would help increase COVID-19 testing while ensuring minimal person-to-person contact being experienced at the testing center. 216 participants took part in this study which was carried out at the Nigerian Institute of Medical Research between June and July 2020. Amongst the 216 participants, 174 tested negatives for both self-collected samples and samples collected by Professionals, 30 tested positive for both arms, with discrepancies occurring in 6 samples where the self-collected samples were positive while the ones collected by the professionals were negative. The same occurred in another set of 6 samples with the self-collected samples being negative and the professional—collected sample coming out positive, with a sensitivity of 83.3% and a specificity of 96.7%. The results of the interrater analysis are Kappa = 0.800 (95% CI, 0.690 to 0.910) which implies an outstanding agreement between the two COVID-19 sampling methods. Furthermore, since p< 0.001 Kappa (k) coefficient is statistically different from zero, our findings have shown that self-collected samples can be reliable in the diagnosis of COVID-19.Olufemi Samuel AmooFunmi AdewaraBosun TijaniTochukwu Ifeanyi OnuigboAmaka Stephanie IkemefunaJoy Isioma OraegbuTazeen RizviAzuka OkwuraiweChika OnwuamahJoseph ShaibuAyorinde JamesGreg OhihoinFehintola IgeDorcas KareithiAgatha DavidSteven KareraHammed AgboolaAnthony AdeniyiJosephine ObiDominic AchanyaEbenezer OdewaleOsaga OforomehGideon LiboroOlayemi NwogbeOliver EzechiRichard AdegbolaRosemary AuduBabatunde SalakoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Olufemi Samuel Amoo Funmi Adewara Bosun Tijani Tochukwu Ifeanyi Onuigbo Amaka Stephanie Ikemefuna Joy Isioma Oraegbu Tazeen Rizvi Azuka Okwuraiwe Chika Onwuamah Joseph Shaibu Ayorinde James Greg Ohihoin Fehintola Ige Dorcas Kareithi Agatha David Steven Karera Hammed Agboola Anthony Adeniyi Josephine Obi Dominic Achanya Ebenezer Odewale Osaga Oforomeh Gideon Liboro Olayemi Nwogbe Oliver Ezechi Richard Adegbola Rosemary Audu Babatunde Salako The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
description	The first case of COVID-19 in Nigeria was recorded on February 27, 2020, being an imported case by an Italian expatriate, to the country. Since then, there has been steady increase in the number of cases. However, the number of cases in Nigeria is low in comparison to cases reported by other countries with similar large populations, despite the poor health system prevailing in the country. This has been mainly attributed to the low testing capacity in Nigeria among other factors. Therefore, there is a need for innovative ways to increase the number of persons testing for COVID-19. The aim of the study was to pilot a nasopharyngeal swab self-sample collection model that would help increase COVID-19 testing while ensuring minimal person-to-person contact being experienced at the testing center. 216 participants took part in this study which was carried out at the Nigerian Institute of Medical Research between June and July 2020. Amongst the 216 participants, 174 tested negatives for both self-collected samples and samples collected by Professionals, 30 tested positive for both arms, with discrepancies occurring in 6 samples where the self-collected samples were positive while the ones collected by the professionals were negative. The same occurred in another set of 6 samples with the self-collected samples being negative and the professional—collected sample coming out positive, with a sensitivity of 83.3% and a specificity of 96.7%. The results of the interrater analysis are Kappa = 0.800 (95% CI, 0.690 to 0.910) which implies an outstanding agreement between the two COVID-19 sampling methods. Furthermore, since p< 0.001 Kappa (k) coefficient is statistically different from zero, our findings have shown that self-collected samples can be reliable in the diagnosis of COVID-19.
format	article
author	Olufemi Samuel Amoo Funmi Adewara Bosun Tijani Tochukwu Ifeanyi Onuigbo Amaka Stephanie Ikemefuna Joy Isioma Oraegbu Tazeen Rizvi Azuka Okwuraiwe Chika Onwuamah Joseph Shaibu Ayorinde James Greg Ohihoin Fehintola Ige Dorcas Kareithi Agatha David Steven Karera Hammed Agboola Anthony Adeniyi Josephine Obi Dominic Achanya Ebenezer Odewale Osaga Oforomeh Gideon Liboro Olayemi Nwogbe Oliver Ezechi Richard Adegbola Rosemary Audu Babatunde Salako
author_facet	Olufemi Samuel Amoo Funmi Adewara Bosun Tijani Tochukwu Ifeanyi Onuigbo Amaka Stephanie Ikemefuna Joy Isioma Oraegbu Tazeen Rizvi Azuka Okwuraiwe Chika Onwuamah Joseph Shaibu Ayorinde James Greg Ohihoin Fehintola Ige Dorcas Kareithi Agatha David Steven Karera Hammed Agboola Anthony Adeniyi Josephine Obi Dominic Achanya Ebenezer Odewale Osaga Oforomeh Gideon Liboro Olayemi Nwogbe Oliver Ezechi Richard Adegbola Rosemary Audu Babatunde Salako
author_sort	Olufemi Samuel Amoo
title	The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
title_short	The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
title_full	The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
title_fullStr	The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
title_full_unstemmed	The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up
title_sort	use of diy (do it yourself) sampling and telemonitoring model for covid-19 qpcr testing scale up
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/94dedcc3178f4ec68e8506279f0a52f4
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The use of DIY (Do it yourself) sampling and telemonitoring model for COVID-19 qPCR testing scale up

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