Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites

Benjamin M Geilich,1 Thomas J Webster21Program in Bioengineering, 2Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USAAbstract: In hospitals and clinics worldwide, medical device surfaces have become a rapidly growing source of nosocomial infections....

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Autores principales:	Geilich BM, Webster TJ
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2013
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/94e095076a5d44959e3b8810ddf69291
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spelling	oai:doaj.org-article:94e095076a5d44959e3b8810ddf692912021-12-02T04:33:07ZReduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites1176-91141178-2013https://doaj.org/article/94e095076a5d44959e3b8810ddf692912013-03-01T00:00:00Zhttp://www.dovepress.com/reduced-adhesion-of-staphylococcus-aureus-to-znopvc-nanocomposites-a12537https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Benjamin M Geilich,1 Thomas J Webster21Program in Bioengineering, 2Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USAAbstract: In hospitals and clinics worldwide, medical device surfaces have become a rapidly growing source of nosocomial infections. In particular, patients requiring mechanical ventilation (and, thus, intubation with an endotracheal tube) for extended lengths of time are faced with a high probability of contracting ventilator-associated pneumonia. Once inserted into the body, the endotracheal tube provides a surface to which bacteria can adhere and form a biofilm (a robust, sticky matrix that provides protection against the host immune system and antibiotic treatment). Adding to the severity of this problem is the spread of bacterial genetic tolerance to antibiotics, in part demonstrated by the recent and significant increase in the prevalence of methicillin-resistant Staphylococcus aureus. To combat these trends, different techniques in biomaterial design must be explored. Recent research has shown that nanomaterials (materials with at least one dimension less than 100 nm) may have the potential to prevent or disrupt bacterial processes that lead to infections. In this study, polyvinyl chloride (PVC) taken from a conventional endotracheal tube was embedded with varying concentrations of zinc oxide (ZnO) nanoparticles. S. aureus biofilms were then grown on these nanocomposite surfaces during a 24-hour culture. Following this, biofilms were removed from the surfaces and the number of colony forming units present was assessed. Bacterial proliferation on the samples embedded with the highest concentration of ZnO nanoparticles was 87% less when compared to the control, indicating that this technique is effective at reducing biofilm formation on PVC surfaces without the use of antibiotics.Keywords: nanomaterials, endotracheal tube, biofilm, zinc oxide, nanoparticles, Staphylococcus aureusGeilich BMWebster TJDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2013, Iss default, Pp 1177-1184 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Geilich BM Webster TJ Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
description	Benjamin M Geilich,1 Thomas J Webster21Program in Bioengineering, 2Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USAAbstract: In hospitals and clinics worldwide, medical device surfaces have become a rapidly growing source of nosocomial infections. In particular, patients requiring mechanical ventilation (and, thus, intubation with an endotracheal tube) for extended lengths of time are faced with a high probability of contracting ventilator-associated pneumonia. Once inserted into the body, the endotracheal tube provides a surface to which bacteria can adhere and form a biofilm (a robust, sticky matrix that provides protection against the host immune system and antibiotic treatment). Adding to the severity of this problem is the spread of bacterial genetic tolerance to antibiotics, in part demonstrated by the recent and significant increase in the prevalence of methicillin-resistant Staphylococcus aureus. To combat these trends, different techniques in biomaterial design must be explored. Recent research has shown that nanomaterials (materials with at least one dimension less than 100 nm) may have the potential to prevent or disrupt bacterial processes that lead to infections. In this study, polyvinyl chloride (PVC) taken from a conventional endotracheal tube was embedded with varying concentrations of zinc oxide (ZnO) nanoparticles. S. aureus biofilms were then grown on these nanocomposite surfaces during a 24-hour culture. Following this, biofilms were removed from the surfaces and the number of colony forming units present was assessed. Bacterial proliferation on the samples embedded with the highest concentration of ZnO nanoparticles was 87% less when compared to the control, indicating that this technique is effective at reducing biofilm formation on PVC surfaces without the use of antibiotics.Keywords: nanomaterials, endotracheal tube, biofilm, zinc oxide, nanoparticles, Staphylococcus aureus
format	article
author	Geilich BM Webster TJ
author_facet	Geilich BM Webster TJ
author_sort	Geilich BM
title	Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
title_short	Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
title_full	Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
title_fullStr	Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
title_full_unstemmed	Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
title_sort	reduced adhesion of staphylococcus aureus to zno/pvc nanocomposites
publisher	Dove Medical Press
publishDate	2013
url	https://doaj.org/article/94e095076a5d44959e3b8810ddf69291
work_keys_str_mv	AT geilichbm reducedadhesionofstaphylococcusaureustoznopvcnanocomposites AT webstertj reducedadhesionofstaphylococcusaureustoznopvcnanocomposites
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Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites

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