Can insects develop resistance to insect pathogenic fungi?

Microevolutionary adaptations and mechanisms of fungal pathogen resistance were explored in a melanic population of the Greater wax moth, Galleria mellonella. Under constant selective pressure from the insect pathogenic fungus Beauveria bassiana, 25(th) generation larvae exhibited significantly enha...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ivan M Dubovskiy, Miranda M A Whitten, Olga N Yaroslavtseva, Carolyn Greig, Vadim Y Kryukov, Ekaterina V Grizanova, Krishnendu Mukherjee, Andreas Vilcinskas, Viktor V Glupov, Tariq M Butt
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94e19d953d974a30b8740d217a933b3b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:94e19d953d974a30b8740d217a933b3b
record_format	dspace
spelling	oai:doaj.org-article:94e19d953d974a30b8740d217a933b3b2021-11-18T07:51:12ZCan insects develop resistance to insect pathogenic fungi?1932-620310.1371/journal.pone.0060248https://doaj.org/article/94e19d953d974a30b8740d217a933b3b2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23560083/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Microevolutionary adaptations and mechanisms of fungal pathogen resistance were explored in a melanic population of the Greater wax moth, Galleria mellonella. Under constant selective pressure from the insect pathogenic fungus Beauveria bassiana, 25(th) generation larvae exhibited significantly enhanced resistance, which was specific to this pathogen and not to another insect pathogenic fungus, Metarhizium anisopliae. Defense and stress management strategies of selected (resistant) and non-selected (susceptible) insect lines were compared to uncover mechanisms underpinning resistance, and the possible cost of those survival strategies. We hypothesize that the insects developed a transgenerationally primed resistance to the fungus B. bassiana, a costly trait that was achieved not by compromising life-history traits but rather by prioritizing and re-allocating pathogen-species-specific augmentations to integumental front-line defenses that are most likely to be encountered by invading fungi. Specifically during B. bassiana infection, systemic immune defenses are suppressed in favour of a more limited but targeted repertoire of enhanced responses in the cuticle and epidermis of the integument (e.g. expression of the fungal enzyme inhibitor IMPI, and cuticular phenoloxidase activity). A range of putative stress-management factors (e.g. antioxidants) is also activated during the specific response of selected insects to B. bassiana but not M. anisopliae. This too occurs primarily in the integument, and probably contributes to antifungal defense and/or helps ameliorate the damage inflicted by the fungus or the host's own immune responses.Ivan M DubovskiyMiranda M A WhittenOlga N YaroslavtsevaCarolyn GreigVadim Y KryukovEkaterina V GrizanovaKrishnendu MukherjeeAndreas VilcinskasViktor V GlupovTariq M ButtPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 4, p e60248 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ivan M Dubovskiy Miranda M A Whitten Olga N Yaroslavtseva Carolyn Greig Vadim Y Kryukov Ekaterina V Grizanova Krishnendu Mukherjee Andreas Vilcinskas Viktor V Glupov Tariq M Butt Can insects develop resistance to insect pathogenic fungi?
description	Microevolutionary adaptations and mechanisms of fungal pathogen resistance were explored in a melanic population of the Greater wax moth, Galleria mellonella. Under constant selective pressure from the insect pathogenic fungus Beauveria bassiana, 25(th) generation larvae exhibited significantly enhanced resistance, which was specific to this pathogen and not to another insect pathogenic fungus, Metarhizium anisopliae. Defense and stress management strategies of selected (resistant) and non-selected (susceptible) insect lines were compared to uncover mechanisms underpinning resistance, and the possible cost of those survival strategies. We hypothesize that the insects developed a transgenerationally primed resistance to the fungus B. bassiana, a costly trait that was achieved not by compromising life-history traits but rather by prioritizing and re-allocating pathogen-species-specific augmentations to integumental front-line defenses that are most likely to be encountered by invading fungi. Specifically during B. bassiana infection, systemic immune defenses are suppressed in favour of a more limited but targeted repertoire of enhanced responses in the cuticle and epidermis of the integument (e.g. expression of the fungal enzyme inhibitor IMPI, and cuticular phenoloxidase activity). A range of putative stress-management factors (e.g. antioxidants) is also activated during the specific response of selected insects to B. bassiana but not M. anisopliae. This too occurs primarily in the integument, and probably contributes to antifungal defense and/or helps ameliorate the damage inflicted by the fungus or the host's own immune responses.
format	article
author	Ivan M Dubovskiy Miranda M A Whitten Olga N Yaroslavtseva Carolyn Greig Vadim Y Kryukov Ekaterina V Grizanova Krishnendu Mukherjee Andreas Vilcinskas Viktor V Glupov Tariq M Butt
author_facet	Ivan M Dubovskiy Miranda M A Whitten Olga N Yaroslavtseva Carolyn Greig Vadim Y Kryukov Ekaterina V Grizanova Krishnendu Mukherjee Andreas Vilcinskas Viktor V Glupov Tariq M Butt
author_sort	Ivan M Dubovskiy
title	Can insects develop resistance to insect pathogenic fungi?
title_short	Can insects develop resistance to insect pathogenic fungi?
title_full	Can insects develop resistance to insect pathogenic fungi?
title_fullStr	Can insects develop resistance to insect pathogenic fungi?
title_full_unstemmed	Can insects develop resistance to insect pathogenic fungi?
title_sort	can insects develop resistance to insect pathogenic fungi?
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/94e19d953d974a30b8740d217a933b3b
work_keys_str_mv	AT ivanmdubovskiy caninsectsdevelopresistancetoinsectpathogenicfungi AT mirandamawhitten caninsectsdevelopresistancetoinsectpathogenicfungi AT olganyaroslavtseva caninsectsdevelopresistancetoinsectpathogenicfungi AT carolyngreig caninsectsdevelopresistancetoinsectpathogenicfungi AT vadimykryukov caninsectsdevelopresistancetoinsectpathogenicfungi AT ekaterinavgrizanova caninsectsdevelopresistancetoinsectpathogenicfungi AT krishnendumukherjee caninsectsdevelopresistancetoinsectpathogenicfungi AT andreasvilcinskas caninsectsdevelopresistancetoinsectpathogenicfungi AT viktorvglupov caninsectsdevelopresistancetoinsectpathogenicfungi AT tariqmbutt caninsectsdevelopresistancetoinsectpathogenicfungi
_version_	1718422868636729344

Can insects develop resistance to insect pathogenic fungi?

Ejemplares similares