Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats

Infected cutaneous ulcers from diabetic rats with <i>Candida albicans</i> and <i>Streptococcus aureus</i> were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound develop...

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Autores principales:	Renan Aparecido Fernandes Scappaticci, Andresa Aparecida Berretta, Elina Cassia Torres, Andrei Felipe Moreira Buszinski, Gabriela Lopes Fernandes, Thaila Fernanda dos Reis, Francisco Nunes de Souza-Neto, Luiz Fernando Gorup, Emerson Rodrigues de Camargo, Debora Barros Barbosa
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	silver nanoparticles <i>Punica granatum</i> wound healing <i>Staphylococcus aureus</i> <i>Candida albicans</i> Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/94e1fcd7a83e47eca0d81b77779f4c4c
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spelling	oai:doaj.org-article:94e1fcd7a83e47eca0d81b77779f4c4c2021-11-25T16:23:13ZGreen and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats10.3390/antibiotics101113432079-6382https://doaj.org/article/94e1fcd7a83e47eca0d81b77779f4c4c2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6382/10/11/1343https://doaj.org/toc/2079-6382Infected cutaneous ulcers from diabetic rats with <i>Candida albicans</i> and <i>Streptococcus aureus</i> were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant <i>S. aureus</i> reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques’ limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included.Renan Aparecido Fernandes ScappaticciAndresa Aparecida BerrettaElina Cassia TorresAndrei Felipe Moreira BuszinskiGabriela Lopes FernandesThaila Fernanda dos ReisFrancisco Nunes de Souza-NetoLuiz Fernando GorupEmerson Rodrigues de CamargoDebora Barros BarbosaMDPI AGarticlesilvernanoparticles<i>Punica granatum</i>wound healing<i>Staphylococcus aureus</i><i>Candida albicans</i>Therapeutics. PharmacologyRM1-950ENAntibiotics, Vol 10, Iss 1343, p 1343 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	silver nanoparticles <i>Punica granatum</i> wound healing <i>Staphylococcus aureus</i> <i>Candida albicans</i> Therapeutics. Pharmacology RM1-950
spellingShingle	silver nanoparticles <i>Punica granatum</i> wound healing <i>Staphylococcus aureus</i> <i>Candida albicans</i> Therapeutics. Pharmacology RM1-950 Renan Aparecido Fernandes Scappaticci Andresa Aparecida Berretta Elina Cassia Torres Andrei Felipe Moreira Buszinski Gabriela Lopes Fernandes Thaila Fernanda dos Reis Francisco Nunes de Souza-Neto Luiz Fernando Gorup Emerson Rodrigues de Camargo Debora Barros Barbosa Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
description	Infected cutaneous ulcers from diabetic rats with <i>Candida albicans</i> and <i>Streptococcus aureus</i> were treated with spray formulations containing green silver nanoparticles (GS), chemical silver nanoparticles (CS), or pomegranate peel extract (PS). After wound development and infection, the treatments were performed twice per day for 14 days. The wound healing was analyzed on days 2, 7, and 14 through the determination of CFUs, inflammatory infiltrate, angiogenesis, fibroplasia, myeloperoxidase, and collagen determination. Expressive improvement in wound healing was noted using both silver nanoparticles for 7 days. All the treatments were superior to controls and promoted significant <i>S. aureus</i> reduction after 14 days. CS presented better anti-inflammatory results, and GS and CS the highest number of fibroblasts. Despite the techniques’ limitations, GS and CS demonstrated considerable potential for managing infected wounds, especially considering no early strategies prior to the drugs, such as the debridement of these wounds, were included.
format	article
author	Renan Aparecido Fernandes Scappaticci Andresa Aparecida Berretta Elina Cassia Torres Andrei Felipe Moreira Buszinski Gabriela Lopes Fernandes Thaila Fernanda dos Reis Francisco Nunes de Souza-Neto Luiz Fernando Gorup Emerson Rodrigues de Camargo Debora Barros Barbosa
author_facet	Renan Aparecido Fernandes Scappaticci Andresa Aparecida Berretta Elina Cassia Torres Andrei Felipe Moreira Buszinski Gabriela Lopes Fernandes Thaila Fernanda dos Reis Francisco Nunes de Souza-Neto Luiz Fernando Gorup Emerson Rodrigues de Camargo Debora Barros Barbosa
author_sort	Renan Aparecido Fernandes Scappaticci
title	Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
title_short	Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
title_full	Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
title_fullStr	Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
title_full_unstemmed	Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats
title_sort	green and chemical silver nanoparticles and pomegranate formulations to heal infected wounds in diabetic rats
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/94e1fcd7a83e47eca0d81b77779f4c4c
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Green and Chemical Silver Nanoparticles and Pomegranate Formulations to Heal Infected Wounds in Diabetic Rats

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