In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions

Abstract There is a wide range of equivocal melanocytic lesions that can be clinically and dermoscopically indistinguishable from early melanoma. In the present work, we assessed the possibilities of combined using of multiphoton microscopy (MPM) and optical coherence angiography (OCA) for different...

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Autores principales:	V. Elagin, E. Gubarkova, O. Garanina, D. Davydova, N. Orlinskaya, L. Matveev, I. Klemenova, I. Shlivko, M. Shirmanova, E. Zagaynova
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94e52fb1c15e4df8898506e0b5bf7989
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spelling	oai:doaj.org-article:94e52fb1c15e4df8898506e0b5bf79892021-12-02T15:23:05ZIn vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions10.1038/s41598-020-80744-w2045-2322https://doaj.org/article/94e52fb1c15e4df8898506e0b5bf79892021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80744-whttps://doaj.org/toc/2045-2322Abstract There is a wide range of equivocal melanocytic lesions that can be clinically and dermoscopically indistinguishable from early melanoma. In the present work, we assessed the possibilities of combined using of multiphoton microscopy (MPM) and optical coherence angiography (OCA) for differential diagnosis of the equivocal melanocytic lesions. Clinical and dermoscopic examinations of 60 melanocytic lesions revealed 10 benign lesions and 32 melanomas, while 18 lesions remained difficult to diagnose. Histopathological analysis of these lesions revealed 4 intradermal, 3 compound and 3 junctional nevi in the “benign” group, 7 superficial spreading, 14 lentigo maligna and 11 nodular melanomas in the “melanoma” group and 2 lentigo simplex, 4 dysplastic nevi, 6 melanomas in situ, 4 invasive lentigo melanomas and 2 invasive superficial spreading melanomas in the “equivocal” group. On the basis of MPM, a multiphoton microscopy score (MPMS) has been developed for quantitative assessment of melanoma features at the cellular level, that showed lower score for benign lesions compare with malignant ones. OCA revealed that the invasive melanoma has a higher vessel density and thicker blood vessels than melanoma in situ and benign lesions. Discriminant functions analysis of MPM and OCA data allowed to differentiate correctly between all equivocal melanocytic lesions. Therefore, we demonstrate, for the first time, that a combined use of MPM and OCA has the potential to improve early diagnosis of melanoma.V. ElaginE. GubarkovaO. GaraninaD. DavydovaN. OrlinskayaL. MatveevI. KlemenovaI. ShlivkoM. ShirmanovaE. ZagaynovaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q V. Elagin E. Gubarkova O. Garanina D. Davydova N. Orlinskaya L. Matveev I. Klemenova I. Shlivko M. Shirmanova E. Zagaynova In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
description	Abstract There is a wide range of equivocal melanocytic lesions that can be clinically and dermoscopically indistinguishable from early melanoma. In the present work, we assessed the possibilities of combined using of multiphoton microscopy (MPM) and optical coherence angiography (OCA) for differential diagnosis of the equivocal melanocytic lesions. Clinical and dermoscopic examinations of 60 melanocytic lesions revealed 10 benign lesions and 32 melanomas, while 18 lesions remained difficult to diagnose. Histopathological analysis of these lesions revealed 4 intradermal, 3 compound and 3 junctional nevi in the “benign” group, 7 superficial spreading, 14 lentigo maligna and 11 nodular melanomas in the “melanoma” group and 2 lentigo simplex, 4 dysplastic nevi, 6 melanomas in situ, 4 invasive lentigo melanomas and 2 invasive superficial spreading melanomas in the “equivocal” group. On the basis of MPM, a multiphoton microscopy score (MPMS) has been developed for quantitative assessment of melanoma features at the cellular level, that showed lower score for benign lesions compare with malignant ones. OCA revealed that the invasive melanoma has a higher vessel density and thicker blood vessels than melanoma in situ and benign lesions. Discriminant functions analysis of MPM and OCA data allowed to differentiate correctly between all equivocal melanocytic lesions. Therefore, we demonstrate, for the first time, that a combined use of MPM and OCA has the potential to improve early diagnosis of melanoma.
format	article
author	V. Elagin E. Gubarkova O. Garanina D. Davydova N. Orlinskaya L. Matveev I. Klemenova I. Shlivko M. Shirmanova E. Zagaynova
author_facet	V. Elagin E. Gubarkova O. Garanina D. Davydova N. Orlinskaya L. Matveev I. Klemenova I. Shlivko M. Shirmanova E. Zagaynova
author_sort	V. Elagin
title	In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
title_short	In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
title_full	In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
title_fullStr	In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
title_full_unstemmed	In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
title_sort	in vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/94e52fb1c15e4df8898506e0b5bf7989
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In vivo multimodal optical imaging of dermoscopic equivocal melanocytic skin lesions

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