Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDA...

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Autores principales:	Cheng-Wei Chou, Yu-Hsiu Hsieh, Su-Chi Ku, Wan-Jou Shen, Gangga Anuraga, Hoang Dang Khoa Ta, Kuen-Haur Lee, Yu-Cheng Lee, Cheng-Hsien Lin, Chih-Yang Wang, Wei-Jan Wang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	pancreatic ductal adenocarcinoma biomarker OSBPL2 OSBPL3 OSBPL5 OSBPL6 Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/94e5dbbc32664b3aa58b1fa9804d5322
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spelling	oai:doaj.org-article:94e5dbbc32664b3aa58b1fa9804d53222021-11-25T16:49:29ZPotential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma10.3390/biomedicines91116012227-9059https://doaj.org/article/94e5dbbc32664b3aa58b1fa9804d53222021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1601https://doaj.org/toc/2227-9059Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDAC and OSBPL family members have not comprehensively been elucidated. In this study, we used the Oncomine and GEPIA 2 databases to analyze OSBPL transcription expressions in PDAC. The Kaplan–Meier plotter and TIMER 2.0 were used to assess the relationships between overall survival (OS) and immune-infiltration with OSBPL family members. Co-expression data from cBioPortal were downloaded to assess the correlated pathways with OSBPL gene family members using DAVID. The expressions of OSBPL3, OSBPL8, OSBPL10, and OSBPL11 were found to be highly upregulated in PDAC. Low expressions of OSBPL3, OSBPL8, and OSBPL10 indicated longer OS. The functions of OSBPL family members were mainly associated with several potential signaling pathways in cancer cells, including ATP binding, integrin binding, receptor binding, and the renin-angiotensin system (RAS) signaling pathway. The transcription levels of OSBPL gene family members were connected with several immune infiltrates. Collectively, OSBPL family members are influential biomarkers for the early diagnosis of PDAC and have prognostic value, with the promise of precise treatment of PDAC in the future.Cheng-Wei ChouYu-Hsiu HsiehSu-Chi KuWan-Jou ShenGangga AnuragaHoang Dang Khoa TaKuen-Haur LeeYu-Cheng LeeCheng-Hsien LinChih-Yang WangWei-Jan WangMDPI AGarticlepancreatic ductal adenocarcinomabiomarkerOSBPL2OSBPL3OSBPL5OSBPL6Biology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1601, p 1601 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	pancreatic ductal adenocarcinoma biomarker OSBPL2 OSBPL3 OSBPL5 OSBPL6 Biology (General) QH301-705.5
spellingShingle	pancreatic ductal adenocarcinoma biomarker OSBPL2 OSBPL3 OSBPL5 OSBPL6 Biology (General) QH301-705.5 Cheng-Wei Chou Yu-Hsiu Hsieh Su-Chi Ku Wan-Jou Shen Gangga Anuraga Hoang Dang Khoa Ta Kuen-Haur Lee Yu-Cheng Lee Cheng-Hsien Lin Chih-Yang Wang Wei-Jan Wang Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
description	Pancreatic ductal adenocarcinoma (PDAC) is a highly fatal malignancy with poor survival outcomes. In addition, oxysterol-binding protein-like (OSBPL) family members are reported to be involved in lipid binding and transport and play critical roles in tumorigenesis. However, relationships between PDAC and OSBPL family members have not comprehensively been elucidated. In this study, we used the Oncomine and GEPIA 2 databases to analyze OSBPL transcription expressions in PDAC. The Kaplan–Meier plotter and TIMER 2.0 were used to assess the relationships between overall survival (OS) and immune-infiltration with OSBPL family members. Co-expression data from cBioPortal were downloaded to assess the correlated pathways with OSBPL gene family members using DAVID. The expressions of OSBPL3, OSBPL8, OSBPL10, and OSBPL11 were found to be highly upregulated in PDAC. Low expressions of OSBPL3, OSBPL8, and OSBPL10 indicated longer OS. The functions of OSBPL family members were mainly associated with several potential signaling pathways in cancer cells, including ATP binding, integrin binding, receptor binding, and the renin-angiotensin system (RAS) signaling pathway. The transcription levels of OSBPL gene family members were connected with several immune infiltrates. Collectively, OSBPL family members are influential biomarkers for the early diagnosis of PDAC and have prognostic value, with the promise of precise treatment of PDAC in the future.
format	article
author	Cheng-Wei Chou Yu-Hsiu Hsieh Su-Chi Ku Wan-Jou Shen Gangga Anuraga Hoang Dang Khoa Ta Kuen-Haur Lee Yu-Cheng Lee Cheng-Hsien Lin Chih-Yang Wang Wei-Jan Wang
author_facet	Cheng-Wei Chou Yu-Hsiu Hsieh Su-Chi Ku Wan-Jou Shen Gangga Anuraga Hoang Dang Khoa Ta Kuen-Haur Lee Yu-Cheng Lee Cheng-Hsien Lin Chih-Yang Wang Wei-Jan Wang
author_sort	Cheng-Wei Chou
title	Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_short	Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_full	Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_fullStr	Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_full_unstemmed	Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma
title_sort	potential prognostic biomarkers of osbpl family genes in patients with pancreatic ductal adenocarcinoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/94e5dbbc32664b3aa58b1fa9804d5322
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Potential Prognostic Biomarkers of OSBPL Family Genes in Patients with Pancreatic Ductal Adenocarcinoma

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