The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.

<h4>Objective</h4>Statins are among the most prescribed drugs worldwide and their recently discovered anti-inflammatory effect seems to have an important role in inhibiting proinflammatory cytokine production, chemokines expression and counteracting the harmful effects of sepsis on the c...

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Autores principales:	Laura Pasin, Giovanni Landoni, Maria Lourdes Castro, Luca Cabrini, Alessandro Belletti, Paolo Feltracco, Gabriele Finco, Andrea Carozzo, Roberto Chiesa, Alberto Zangrillo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94e802cd9f304d429401605075942fef
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spelling	oai:doaj.org-article:94e802cd9f304d429401605075942fef2021-11-18T08:39:41ZThe effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.1932-620310.1371/journal.pone.0082775https://doaj.org/article/94e802cd9f304d429401605075942fef2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391721/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Statins are among the most prescribed drugs worldwide and their recently discovered anti-inflammatory effect seems to have an important role in inhibiting proinflammatory cytokine production, chemokines expression and counteracting the harmful effects of sepsis on the coagulation system. We decided to perform a meta-analysis of all randomized controlled trials ever published on statin therapy in septic patients to evaluate their effect on survival and length of hospital stay.<h4>Data sources and study selection</h4>Articles were assessed by four trained investigators, with divergences resolved by consensus. BioMedCentral, PubMed, Embase and the Cochrane Central Register of clinical trials were searched for pertinent studies. Inclusion criteria were random allocation to treatment and comparison of statins versus any comparator in septic patients.<h4>Data extraction and synthesis</h4>Data from 650 patients in 5 randomized controlled studies were analyzed. No difference in mortality between patients receiving statins versus control (44/322 [14%] in the statins group vs 50/328 [15%] in the control arm, RR = 0.90 [95% CI 0.65 to 1.26], p = 0.6) was observed. No differences in hospital stay (p = 0.7) were found.<h4>Conclusions</h4>Published data show that statin therapy has no effect on mortality in the overall population of adult septic patients. Scientific evidence on statins role in septic patients is still limited and larger randomized trials should be performed on this topic.Laura PasinGiovanni LandoniMaria Lourdes CastroLuca CabriniAlessandro BellettiPaolo FeltraccoGabriele FincoAndrea CarozzoRoberto ChiesaAlberto ZangrilloPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e82775 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Laura Pasin Giovanni Landoni Maria Lourdes Castro Luca Cabrini Alessandro Belletti Paolo Feltracco Gabriele Finco Andrea Carozzo Roberto Chiesa Alberto Zangrillo The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
description	<h4>Objective</h4>Statins are among the most prescribed drugs worldwide and their recently discovered anti-inflammatory effect seems to have an important role in inhibiting proinflammatory cytokine production, chemokines expression and counteracting the harmful effects of sepsis on the coagulation system. We decided to perform a meta-analysis of all randomized controlled trials ever published on statin therapy in septic patients to evaluate their effect on survival and length of hospital stay.<h4>Data sources and study selection</h4>Articles were assessed by four trained investigators, with divergences resolved by consensus. BioMedCentral, PubMed, Embase and the Cochrane Central Register of clinical trials were searched for pertinent studies. Inclusion criteria were random allocation to treatment and comparison of statins versus any comparator in septic patients.<h4>Data extraction and synthesis</h4>Data from 650 patients in 5 randomized controlled studies were analyzed. No difference in mortality between patients receiving statins versus control (44/322 [14%] in the statins group vs 50/328 [15%] in the control arm, RR = 0.90 [95% CI 0.65 to 1.26], p = 0.6) was observed. No differences in hospital stay (p = 0.7) were found.<h4>Conclusions</h4>Published data show that statin therapy has no effect on mortality in the overall population of adult septic patients. Scientific evidence on statins role in septic patients is still limited and larger randomized trials should be performed on this topic.
format	article
author	Laura Pasin Giovanni Landoni Maria Lourdes Castro Luca Cabrini Alessandro Belletti Paolo Feltracco Gabriele Finco Andrea Carozzo Roberto Chiesa Alberto Zangrillo
author_facet	Laura Pasin Giovanni Landoni Maria Lourdes Castro Luca Cabrini Alessandro Belletti Paolo Feltracco Gabriele Finco Andrea Carozzo Roberto Chiesa Alberto Zangrillo
author_sort	Laura Pasin
title	The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
title_short	The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
title_full	The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
title_fullStr	The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
title_full_unstemmed	The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
title_sort	effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/94e802cd9f304d429401605075942fef
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The effect of statins on mortality in septic patients: a meta-analysis of randomized controlled trials.

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