Trends and patterns in the use of opioids among metastatic breast cancer patients

Abstract Opioid use among metastatic breast cancer (MBC) patients has not been well-studied. This study examined the trends and patterns of opioid use among working-age, privately insured patients diagnosed with MBC. Using MarketScan data, we identified female patients diagnosed with MBC in 2006–201...

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Autores principales:	Chan Shen, J. Douglas Thornton, Kristina Newport, Eric Schaefer, Shouhao Zhou, Nelson S. Yee, Daleela Dodge, Douglas Leslie
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94ea605652a047358ef5305475d77a24
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spelling	oai:doaj.org-article:94ea605652a047358ef5305475d77a242021-12-02T16:18:03ZTrends and patterns in the use of opioids among metastatic breast cancer patients10.1038/s41598-020-78569-82045-2322https://doaj.org/article/94ea605652a047358ef5305475d77a242020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-78569-8https://doaj.org/toc/2045-2322Abstract Opioid use among metastatic breast cancer (MBC) patients has not been well-studied. This study examined the trends and patterns of opioid use among working-age, privately insured patients diagnosed with MBC. Using MarketScan data, we identified female patients diagnosed with MBC in 2006–2015. We determined the proportion of patients who filled a prescription for an opioid and calculated days’ supply and daily morphine milligram equivalents (MMEs) from 1 year prior to diagnosis till 1 year after. We assessed the trend in opioid use over the 10-year study period and examined opioid usage patterns after the diagnosis of MBC. Among 24,752 patients included, 11,579 (46.8%) had an opioid prescription within 1 year before diagnosis of MBC, and 20,416 (81.4%) had an opioid prescription within 1 year after diagnosis. The proportion of patients with opioid prescriptions after diagnosis was relatively stable from 2006 to 2015. However, both the median daily MME and median days’ supply decreased over time with most of the decline from the subgroup of patients with prior prescription opioid use. Most patients received an opioid prescription in the first month after diagnosis (57.3%), dropping to approximately 20% from 3 to 12 months after diagnosis. Also, the median days’ supply increased substantially during the year after diagnosis for patients who received opioids (from 7 to 19). Most women with MBC require opioid analgesia within the first month after diagnosis. Judicious, long-term management of pain after diagnosis of MBC will continue to be necessary for many patients.Chan ShenJ. Douglas ThorntonKristina NewportEric SchaeferShouhao ZhouNelson S. YeeDaleela DodgeDouglas LeslieNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Chan Shen J. Douglas Thornton Kristina Newport Eric Schaefer Shouhao Zhou Nelson S. Yee Daleela Dodge Douglas Leslie Trends and patterns in the use of opioids among metastatic breast cancer patients
description	Abstract Opioid use among metastatic breast cancer (MBC) patients has not been well-studied. This study examined the trends and patterns of opioid use among working-age, privately insured patients diagnosed with MBC. Using MarketScan data, we identified female patients diagnosed with MBC in 2006–2015. We determined the proportion of patients who filled a prescription for an opioid and calculated days’ supply and daily morphine milligram equivalents (MMEs) from 1 year prior to diagnosis till 1 year after. We assessed the trend in opioid use over the 10-year study period and examined opioid usage patterns after the diagnosis of MBC. Among 24,752 patients included, 11,579 (46.8%) had an opioid prescription within 1 year before diagnosis of MBC, and 20,416 (81.4%) had an opioid prescription within 1 year after diagnosis. The proportion of patients with opioid prescriptions after diagnosis was relatively stable from 2006 to 2015. However, both the median daily MME and median days’ supply decreased over time with most of the decline from the subgroup of patients with prior prescription opioid use. Most patients received an opioid prescription in the first month after diagnosis (57.3%), dropping to approximately 20% from 3 to 12 months after diagnosis. Also, the median days’ supply increased substantially during the year after diagnosis for patients who received opioids (from 7 to 19). Most women with MBC require opioid analgesia within the first month after diagnosis. Judicious, long-term management of pain after diagnosis of MBC will continue to be necessary for many patients.
format	article
author	Chan Shen J. Douglas Thornton Kristina Newport Eric Schaefer Shouhao Zhou Nelson S. Yee Daleela Dodge Douglas Leslie
author_facet	Chan Shen J. Douglas Thornton Kristina Newport Eric Schaefer Shouhao Zhou Nelson S. Yee Daleela Dodge Douglas Leslie
author_sort	Chan Shen
title	Trends and patterns in the use of opioids among metastatic breast cancer patients
title_short	Trends and patterns in the use of opioids among metastatic breast cancer patients
title_full	Trends and patterns in the use of opioids among metastatic breast cancer patients
title_fullStr	Trends and patterns in the use of opioids among metastatic breast cancer patients
title_full_unstemmed	Trends and patterns in the use of opioids among metastatic breast cancer patients
title_sort	trends and patterns in the use of opioids among metastatic breast cancer patients
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/94ea605652a047358ef5305475d77a24
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Trends and patterns in the use of opioids among metastatic breast cancer patients

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