Structural disorder in eukaryotes.

Based on early bioinformatic studies on a handful of species, the frequency of structural disorder of proteins is generally thought to be much higher in eukaryotes than in prokaryotes. To refine this view, we present here a comparative prediction study and analysis of 194 fully described eukaryotic...

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Autores principales:	Rita Pancsa, Peter Tompa
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94edbf730b0f4d248ad469d58414c17a
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spelling	oai:doaj.org-article:94edbf730b0f4d248ad469d58414c17a2021-11-18T07:23:07ZStructural disorder in eukaryotes.1932-620310.1371/journal.pone.0034687https://doaj.org/article/94edbf730b0f4d248ad469d58414c17a2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22496841/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Based on early bioinformatic studies on a handful of species, the frequency of structural disorder of proteins is generally thought to be much higher in eukaryotes than in prokaryotes. To refine this view, we present here a comparative prediction study and analysis of 194 fully described eukaryotic proteomes and 87 reference prokaryotes for structural disorder. We found that structural disorder does distinguish eukaryotes from prokaryotes, but its frequency spans a very wide range in the two superkingdoms that largely overlap. The number of disordered binding regions and different Pfam domain types also contribute to distinguish eukaryotes from prokaryotes. Unexpectedly, the highest levels--and highest variability--of predicted disorder is found in protists, i.e. single-celled eukaryotes, often surpassing more complex eukaryote organisms, plants and animals. This trend contrasts with that of the number of domain types, which increases rather monotonously toward more complex organisms. The level of structural disorder appears to be strongly correlated with lifestyle, because some obligate intracellular parasites and endosymbionts have the lowest levels, whereas host-changing parasites have the highest level of predicted disorder. We conclude that protists have been the evolutionary hot-bed of experimentation with structural disorder, in a period when structural disorder was actively invented and the major functional classes of disordered proteins established.Rita PancsaPeter TompaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 4, p e34687 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rita Pancsa Peter Tompa Structural disorder in eukaryotes.
description	Based on early bioinformatic studies on a handful of species, the frequency of structural disorder of proteins is generally thought to be much higher in eukaryotes than in prokaryotes. To refine this view, we present here a comparative prediction study and analysis of 194 fully described eukaryotic proteomes and 87 reference prokaryotes for structural disorder. We found that structural disorder does distinguish eukaryotes from prokaryotes, but its frequency spans a very wide range in the two superkingdoms that largely overlap. The number of disordered binding regions and different Pfam domain types also contribute to distinguish eukaryotes from prokaryotes. Unexpectedly, the highest levels--and highest variability--of predicted disorder is found in protists, i.e. single-celled eukaryotes, often surpassing more complex eukaryote organisms, plants and animals. This trend contrasts with that of the number of domain types, which increases rather monotonously toward more complex organisms. The level of structural disorder appears to be strongly correlated with lifestyle, because some obligate intracellular parasites and endosymbionts have the lowest levels, whereas host-changing parasites have the highest level of predicted disorder. We conclude that protists have been the evolutionary hot-bed of experimentation with structural disorder, in a period when structural disorder was actively invented and the major functional classes of disordered proteins established.
format	article
author	Rita Pancsa Peter Tompa
author_facet	Rita Pancsa Peter Tompa
author_sort	Rita Pancsa
title	Structural disorder in eukaryotes.
title_short	Structural disorder in eukaryotes.
title_full	Structural disorder in eukaryotes.
title_fullStr	Structural disorder in eukaryotes.
title_full_unstemmed	Structural disorder in eukaryotes.
title_sort	structural disorder in eukaryotes.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/94edbf730b0f4d248ad469d58414c17a
work_keys_str_mv	AT ritapancsa structuraldisorderineukaryotes AT petertompa structuraldisorderineukaryotes
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Structural disorder in eukaryotes.

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