Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men

Abstract Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were...

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Autores principales:	Shufang Cui, Biao Sun, Xin Yin, Xia Guo, Dingming Chao, Chunni Zhang, Chen-Yu Zhang, Xi Chen, Jizheng Ma
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/94ef1a7462824c1ea5302b1b6f262c75
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spelling	oai:doaj.org-article:94ef1a7462824c1ea5302b1b6f262c752021-12-02T11:41:12ZTime-course responses of circulating microRNAs to three resistance training protocols in healthy young men10.1038/s41598-017-02294-y2045-2322https://doaj.org/article/94ef1a7462824c1ea5302b1b6f262c752017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02294-yhttps://doaj.org/toc/2045-2322Abstract Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three groups: muscular strength endurance (SE), muscular hypertrophy (MH) and maximum strength (MS). Venous blood samples were obtained before exercise and immediately, 1 h and 24 h after each RT protocol to assess the following biological parameters: c-miRNAs, anabolic and catabolic hormones, inflammatory cytokines and muscle damage markers. The results revealed that the levels of two c-miRNAs (miR-208b and miR-532), six c-miRNAs (miR-133a, miR-133b, miR-206, miR-181a, miR-21 and miR-221) and two c-miRNAs (miR-133a and miR-133b) changed significantly in response to the SE, MH and MS protocols (p < 0.05), respectively. The nature and dynamic processes of the c-miRNAs response were likely influenced by the RT modality and intensity. Moreover, miR-532 was negatively correlated with insulin-like growth factor-1 and positively correlated with interleukin-10, whereas miR-133a was negatively correlated with cortisol and positively correlated with testosterone/cortisol. These findings suggest that these c-miRNAs may serve as markers for monitoring the RT responses.Shufang CuiBiao SunXin YinXia GuoDingming ChaoChunni ZhangChen-Yu ZhangXi ChenJizheng MaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shufang Cui Biao Sun Xin Yin Xia Guo Dingming Chao Chunni Zhang Chen-Yu Zhang Xi Chen Jizheng Ma Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men
description	Abstract Circulating microRNAs (c-miRNAs) in human plasma have been described as a potential marker of exercise. The present study investigated the effects of three acute resistance training (RT) protocols on the time-course changes of the c-miRNAs profiles in young males. The subjects (n = 45) were randomly divided into three groups: muscular strength endurance (SE), muscular hypertrophy (MH) and maximum strength (MS). Venous blood samples were obtained before exercise and immediately, 1 h and 24 h after each RT protocol to assess the following biological parameters: c-miRNAs, anabolic and catabolic hormones, inflammatory cytokines and muscle damage markers. The results revealed that the levels of two c-miRNAs (miR-208b and miR-532), six c-miRNAs (miR-133a, miR-133b, miR-206, miR-181a, miR-21 and miR-221) and two c-miRNAs (miR-133a and miR-133b) changed significantly in response to the SE, MH and MS protocols (p < 0.05), respectively. The nature and dynamic processes of the c-miRNAs response were likely influenced by the RT modality and intensity. Moreover, miR-532 was negatively correlated with insulin-like growth factor-1 and positively correlated with interleukin-10, whereas miR-133a was negatively correlated with cortisol and positively correlated with testosterone/cortisol. These findings suggest that these c-miRNAs may serve as markers for monitoring the RT responses.
format	article
author	Shufang Cui Biao Sun Xin Yin Xia Guo Dingming Chao Chunni Zhang Chen-Yu Zhang Xi Chen Jizheng Ma
author_facet	Shufang Cui Biao Sun Xin Yin Xia Guo Dingming Chao Chunni Zhang Chen-Yu Zhang Xi Chen Jizheng Ma
author_sort	Shufang Cui
title	Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men
title_short	Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men
title_full	Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men
title_fullStr	Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men
title_full_unstemmed	Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men
title_sort	time-course responses of circulating micrornas to three resistance training protocols in healthy young men
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94ef1a7462824c1ea5302b1b6f262c75
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Time-course responses of circulating microRNAs to three resistance training protocols in healthy young men

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