Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

Cell cycle: Breast cancer subtypes exhibit distinct checkpoint dysfunctions Unique subtypes of breast cancer display distinctive patterns of genomic instability that affect cell division. Jacquelyn J. Bower and colleagues at the University of North Carolina at Chapel Hill, USA, assessed the molecula...

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Autores principales:	Jacquelyn J. Bower, Leah D. Vance, Matthew Psioda, Stephanie L. Smith-Roe, Dennis A. Simpson, Joseph G. Ibrahim, Katherine A. Hoadley, Charles M. Perou, William K. Kaufmann
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/94f441a22a494a089060ea8ad3b50c9e
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spelling	oai:doaj.org-article:94f441a22a494a089060ea8ad3b50c9e2021-12-02T11:50:52ZPatterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells10.1038/s41523-017-0009-72374-4677https://doaj.org/article/94f441a22a494a089060ea8ad3b50c9e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41523-017-0009-7https://doaj.org/toc/2374-4677Cell cycle: Breast cancer subtypes exhibit distinct checkpoint dysfunctions Unique subtypes of breast cancer display distinctive patterns of genomic instability that affect cell division. Jacquelyn J. Bower and colleagues at the University of North Carolina at Chapel Hill, USA, assessed the molecular function of several G2-M cell cycle checkpoints—which ensure that cells don’t begin mitotic cell division until DNA replication is complete and they have had a chance to repair any damaged DNA—in 24 breast cancer and mammary epithelial cell lines that collectively represent four of the six intrinsic molecular subtypes of breast cancer. The distinct patterns of cell cycle checkpoint deregulation that the researchers found suggest that pharmacological targeting of the dysfunction in each type of breast cancer could lead to personalized treatment strategies. The findings also point to diagnostic biomarkers that could help predict patient responses to novel drugs or existing chemotherapies.Jacquelyn J. BowerLeah D. VanceMatthew PsiodaStephanie L. Smith-RoeDennis A. SimpsonJoseph G. IbrahimKatherine A. HoadleyCharles M. PerouWilliam K. KaufmannNature PortfolioarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENnpj Breast Cancer, Vol 3, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Jacquelyn J. Bower Leah D. Vance Matthew Psioda Stephanie L. Smith-Roe Dennis A. Simpson Joseph G. Ibrahim Katherine A. Hoadley Charles M. Perou William K. Kaufmann Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
description	Cell cycle: Breast cancer subtypes exhibit distinct checkpoint dysfunctions Unique subtypes of breast cancer display distinctive patterns of genomic instability that affect cell division. Jacquelyn J. Bower and colleagues at the University of North Carolina at Chapel Hill, USA, assessed the molecular function of several G2-M cell cycle checkpoints—which ensure that cells don’t begin mitotic cell division until DNA replication is complete and they have had a chance to repair any damaged DNA—in 24 breast cancer and mammary epithelial cell lines that collectively represent four of the six intrinsic molecular subtypes of breast cancer. The distinct patterns of cell cycle checkpoint deregulation that the researchers found suggest that pharmacological targeting of the dysfunction in each type of breast cancer could lead to personalized treatment strategies. The findings also point to diagnostic biomarkers that could help predict patient responses to novel drugs or existing chemotherapies.
format	article
author	Jacquelyn J. Bower Leah D. Vance Matthew Psioda Stephanie L. Smith-Roe Dennis A. Simpson Joseph G. Ibrahim Katherine A. Hoadley Charles M. Perou William K. Kaufmann
author_facet	Jacquelyn J. Bower Leah D. Vance Matthew Psioda Stephanie L. Smith-Roe Dennis A. Simpson Joseph G. Ibrahim Katherine A. Hoadley Charles M. Perou William K. Kaufmann
author_sort	Jacquelyn J. Bower
title	Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
title_short	Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
title_full	Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
title_fullStr	Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
title_full_unstemmed	Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
title_sort	patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/94f441a22a494a089060ea8ad3b50c9e
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Patterns of cell cycle checkpoint deregulation associated with intrinsic molecular subtypes of human breast cancer cells

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