Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques

Ali A Khorasani,1–3 James L Weaver,4 Carolina Salvador-Morales2,3 1Department of Chemistry and Biochemistry, 2Bioengineering Department, 3Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA; 4Division of Applied Regulatory Science, Center for Drug Evaluation a...

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Autores principales:	Khorasani AA, Weaver JL, Salvador-Morales C
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/94f4ab8d80ae4014be5e7e3378e4d2dc
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spelling	oai:doaj.org-article:94f4ab8d80ae4014be5e7e3378e4d2dc2021-12-02T07:46:33ZClosing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques1178-2013https://doaj.org/article/94f4ab8d80ae4014be5e7e3378e4d2dc2014-12-01T00:00:00Zhttp://www.dovepress.com/closing-the-gap-accelerating-the-translational-process-in-nanomedicine-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Ali A Khorasani,1–3 James L Weaver,4 Carolina Salvador-Morales2,3 1Department of Chemistry and Biochemistry, 2Bioengineering Department, 3Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA; 4Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Abstract: On the cusp of widespread permeation of nanomedicine, academia, industry, and government have invested substantial financial resources in developing new ways to better treat diseases. Materials have unique physical and chemical properties at the nanoscale compared with their bulk or small-molecule analogs. These unique properties have been greatly advantageous in providing innovative solutions for medical treatments at the bench level. However, nanomedicine research has not yet fully permeated the clinical setting because of several limitations. Among these limitations are the lack of universal standards for characterizing nanomaterials and the limited knowledge that we possess regarding the interactions between nanomaterials and biological entities such as proteins. In this review, we report on recent developments in the characterization of nanomaterials as well as the newest information about the interactions between nanomaterials and proteins in the human body. We propose a standard set of techniques for universal characterization of nanomaterials. We also address relevant regulatory issues involved in the translational process for the development of drug molecules and drug delivery systems. Adherence and refinement of a universal standard in nanomaterial characterization as well as the acquisition of a deeper understanding of nanomaterials and proteins will likely accelerate the use of nanomedicine in common practice to a great extent. Keywords: physicochemical characterization, poly(ethylene glycol), protein adsorption, regulatory issuesKhorasani AAWeaver JLSalvador-Morales CDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2014, Iss Issue 1, Pp 5729-5751 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Khorasani AA Weaver JL Salvador-Morales C Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
description	Ali A Khorasani,1–3 James L Weaver,4 Carolina Salvador-Morales2,3 1Department of Chemistry and Biochemistry, 2Bioengineering Department, 3Krasnow Institute for Advanced Study, George Mason University, Fairfax, VA, USA; 4Division of Applied Regulatory Science, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA Abstract: On the cusp of widespread permeation of nanomedicine, academia, industry, and government have invested substantial financial resources in developing new ways to better treat diseases. Materials have unique physical and chemical properties at the nanoscale compared with their bulk or small-molecule analogs. These unique properties have been greatly advantageous in providing innovative solutions for medical treatments at the bench level. However, nanomedicine research has not yet fully permeated the clinical setting because of several limitations. Among these limitations are the lack of universal standards for characterizing nanomaterials and the limited knowledge that we possess regarding the interactions between nanomaterials and biological entities such as proteins. In this review, we report on recent developments in the characterization of nanomaterials as well as the newest information about the interactions between nanomaterials and proteins in the human body. We propose a standard set of techniques for universal characterization of nanomaterials. We also address relevant regulatory issues involved in the translational process for the development of drug molecules and drug delivery systems. Adherence and refinement of a universal standard in nanomaterial characterization as well as the acquisition of a deeper understanding of nanomaterials and proteins will likely accelerate the use of nanomedicine in common practice to a great extent. Keywords: physicochemical characterization, poly(ethylene glycol), protein adsorption, regulatory issues
format	article
author	Khorasani AA Weaver JL Salvador-Morales C
author_facet	Khorasani AA Weaver JL Salvador-Morales C
author_sort	Khorasani AA
title	Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
title_short	Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
title_full	Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
title_fullStr	Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
title_full_unstemmed	Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
title_sort	closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/94f4ab8d80ae4014be5e7e3378e4d2dc
work_keys_str_mv	AT khorasaniaa closingthegapacceleratingthetranslationalprocessinnanomedicinebyproposingstandardizedcharacterizationtechniques AT weaverjl closingthegapacceleratingthetranslationalprocessinnanomedicinebyproposingstandardizedcharacterizationtechniques AT salvadormoralesc closingthegapacceleratingthetranslationalprocessinnanomedicinebyproposingstandardizedcharacterizationtechniques
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Closing the gap: accelerating the translational process in nanomedicine by proposing standardized characterization techniques

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