Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes

Abstract Background Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. Methods More than 100,000 subjects with normal glucose at baseline received f...

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Autores principales:	Chunyuan Jiang, Ruijuan Yang, Maobin Kuang, Meng Yu, Mingchun Zhong, Yang Zou
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Pre-diabetes TyG-BMI World Health Organization Triglyceride glucose-body mass index American Diabetes Association Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/9502374bd1004f9094bfba603bea9545
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spelling	oai:doaj.org-article:9502374bd1004f9094bfba603bea95452021-11-14T12:39:44ZTriglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes10.1186/s12944-021-01594-71476-511Xhttps://doaj.org/article/9502374bd1004f9094bfba603bea95452021-11-01T00:00:00Zhttps://doi.org/10.1186/s12944-021-01594-7https://doaj.org/toc/1476-511XAbstract Background Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. Methods More than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event of concern was pre-diabetes defined according to the diagnostic criteria recommended by the American Diabetes Association (ADA) in 2018 and the World Health Organization (WHO) in 1999. A Cox proportional hazard regression model was used to evaluate the role of TyG-BMI in identifying people at high risk of pre-diabetes. Results At a mean observation period of 3.1 years, the incidence of pre-diabetes in the cohort was 3.70 and 12.31% according to the WHO and ADA diagnostic criteria for pre-diabetes, respectively. The multivariate Cox regression analysis demonstrated that TyG-BMI was independently positively correlated with pre-diabetes, and there was a special population dependence phenomenon. Among them, non-obese people, women and people under 50 years old had a significantly higher risk of TyG-BMI-related pre-diabetes (P-interaction< 0.05). Conclusions These findings suggest that a higher TyG-BMI significantly increases an individual’s risk of pre-diabetes, and this risk is significantly higher in women, non-obese individuals, and individuals younger than 50 years of age.Chunyuan JiangRuijuan YangMaobin KuangMeng YuMingchun ZhongYang ZouBMCarticlePre-diabetesTyG-BMIWorld Health OrganizationTriglyceride glucose-body mass indexAmerican Diabetes AssociationNutritional diseases. Deficiency diseasesRC620-627ENLipids in Health and Disease, Vol 20, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Pre-diabetes TyG-BMI World Health Organization Triglyceride glucose-body mass index American Diabetes Association Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	Pre-diabetes TyG-BMI World Health Organization Triglyceride glucose-body mass index American Diabetes Association Nutritional diseases. Deficiency diseases RC620-627 Chunyuan Jiang Ruijuan Yang Maobin Kuang Meng Yu Mingchun Zhong Yang Zou Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
description	Abstract Background Triglyceride glucose-body mass index (TyG-BMI) has been recommended as an alternative indicator of insulin resistance. However, the association between TyG-BMI and pre-diabetes remains to be elucidated. Methods More than 100,000 subjects with normal glucose at baseline received follow-up. The main outcome event of concern was pre-diabetes defined according to the diagnostic criteria recommended by the American Diabetes Association (ADA) in 2018 and the World Health Organization (WHO) in 1999. A Cox proportional hazard regression model was used to evaluate the role of TyG-BMI in identifying people at high risk of pre-diabetes. Results At a mean observation period of 3.1 years, the incidence of pre-diabetes in the cohort was 3.70 and 12.31% according to the WHO and ADA diagnostic criteria for pre-diabetes, respectively. The multivariate Cox regression analysis demonstrated that TyG-BMI was independently positively correlated with pre-diabetes, and there was a special population dependence phenomenon. Among them, non-obese people, women and people under 50 years old had a significantly higher risk of TyG-BMI-related pre-diabetes (P-interaction< 0.05). Conclusions These findings suggest that a higher TyG-BMI significantly increases an individual’s risk of pre-diabetes, and this risk is significantly higher in women, non-obese individuals, and individuals younger than 50 years of age.
format	article
author	Chunyuan Jiang Ruijuan Yang Maobin Kuang Meng Yu Mingchun Zhong Yang Zou
author_facet	Chunyuan Jiang Ruijuan Yang Maobin Kuang Meng Yu Mingchun Zhong Yang Zou
author_sort	Chunyuan Jiang
title	Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
title_short	Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
title_full	Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
title_fullStr	Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
title_full_unstemmed	Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
title_sort	triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes
publisher	BMC
publishDate	2021
url	https://doaj.org/article/9502374bd1004f9094bfba603bea9545
work_keys_str_mv	AT chunyuanjiang triglycerideglucosebodymassindexinidentifyinghighriskgroupsofprediabetes AT ruijuanyang triglycerideglucosebodymassindexinidentifyinghighriskgroupsofprediabetes AT maobinkuang triglycerideglucosebodymassindexinidentifyinghighriskgroupsofprediabetes AT mengyu triglycerideglucosebodymassindexinidentifyinghighriskgroupsofprediabetes AT mingchunzhong triglycerideglucosebodymassindexinidentifyinghighriskgroupsofprediabetes AT yangzou triglycerideglucosebodymassindexinidentifyinghighriskgroupsofprediabetes
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Triglyceride glucose-body mass index in identifying high-risk groups of pre-diabetes

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